FACTORS INFLUENCING PLASMA-CATECHOLAMINE LEVELS IN RATS DURING IMMOBILIZATION
FACTORS INFLUENCING PLASMA-CATECHOLAMINE LEVELS IN RATS DURING IMMOBILIZATION
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DOI：
10.1016/0091-3057(80)90132-x
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发表时间：
1980-01-01
影响因子：
3.6
通讯作者：
VOGEL, WH
中科院分区：
文献类型：
--
作者：
DETURCK, KH;VOGEL, WH
将动情期和间情期的幼年和老年雄性和雌性大鼠留置导尿管30min。连续采血1小时以上，测定血浆中儿茶酚胺(CA)、去甲肾上腺素(NE)和肾上腺素(E)的含量。清醒的年轻雄性大鼠的基础CA水平高于睡眠的雄性大鼠，老年雄性大鼠的CA水平仍然较高。基础去甲肾上腺素水平以发情间期女性最高。各组固定后血浆CA水平升高趋势相似。峰值出现在1-5min，此后缓慢下降至基线水平。幼年雄性大鼠反复应激导致习服，表现为在第二和第三次束缚时CA峰值水平降低。在雌性大鼠中，年龄、暴露时间和周期的天数对制动期间和制动后不同时间的CA水平以及总的应激反应有细微的影响，但在统计学上具有显著意义。
Catheterized young and old male and female rats in estrus and diestrus were immobilized for 30 min periods. Serial blood samples [6] were drawn over 1 h and the plasma was assayed for the catecholamines (CA), norepinephrine (NE) and epinephrine (E). Baseline CA levels were higher in awake young male rats than in asleep males and still higher in old male rats. Highest basal NE levels were found in diestrus females. Immobilization produced similar elevations in plasma CA for all groups. Peak values occurred at 1-5 min and declined slowly thereafter toward baseline. Repeated stress of young male rats caused habituation as evidenced by diminished peak CA levels during the 2nd and 3rd restraint. Age, time of exposure and day of the cycle in female rats had subtle, although statistically significant, effects on CA levels at various times during and after immobilization and on the total stress response.