A Long-Term Follow-Up Study on Endoscopic Management of Children and Adolescents With Chronic Pancreatitis
A Long-Term Follow-Up Study on Endoscopic Management of Children and Adolescents With Chronic Pancreatitis
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儿童和青少年慢性胰腺炎内镜治疗的长期随访研究。
DOI：
10.1038/ajg.2010.85
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发表时间：
2010-08-01
影响因子：
9.8
通讯作者：
Wang, Li
中科院分区：
文献类型：
--
作者：
Li, Zhao-Shen;Wang, Wei;Wang, Li
目的：关于儿童和青少年慢性胰腺炎（CP）治疗性内镜逆行胰胆管造影（ERCP）的数据，特别是长期随访结果的数据很少报道。本研究的目的是确定治疗性ERCP治疗儿童和青少年CP的长期随访结果。方法：纳入1997年1月至2009年5月在长海医院接受治疗性ERCP的所有CP患者，首次疼痛发作时年龄小于18.0岁。尝试联系所有青少年并记录随访数据。结果：46例接受治疗性ERCP的患者中，42例（91.3%）获得随访信息。有20名男孩和22名女孩，首次发病年龄为11.8 +/- 4.5岁。42例患者共进行了110次治疗性ERCP检查。ERCP术后并发症发生率为17.3%，包括轻中度胰腺炎（n = 17）和轻度胆管炎（n = 2）。平均随访时间为61.4（范围：24-132）个月。5例患者在内镜治疗后因顽固性腹痛接受了后续手术。其余37例单独接受治疗性内镜逆行胰胆管造影的患者中，30例（81.1%）患者的腹痛在随访期间得到改善，24例（64.9%）患者的腹痛在随访期间完全缓解。结论：治疗性内镜逆行胰胆管造影可以长期改善儿童和青少年CP的疼痛。
OBJECTIVES: Data on therapeutic endoscopic retrograde cholangiopancreatography (ERCP) for chronic pancreatitis (CP) in children and adolescents, especially with long-term follow-up of consequences, are rarely reported. The aim of this study was to determine the long-term follow-up results of therapeutic ERCP for CP in children and adolescents.METHODS: All patients with CP who received therapeutic ERCP at Changhai Hospital from January 1997 to May 2009, with the age at first onset of pain being less than 18.0 years, were included. Attempts were made to contact all adolescents and follow-up data were recorded. Clinical data were assessed before and after every ERCP.RESULTS: Follow-up information was available in 42 (91.3%) of the 46 patients who received therapeutic ERCP. There were 20 boys and 22 girls, with the age at first onset being 11.8 +/- 4.5 years. A total of 110 therapeutic ERCP sessions were performed in the 42 patients. The post-ERCP complication rate was 17.3%, including mild and moderate pancreatitis (n = 17) and mild cholangitis (n = 2). The mean follow-up period of time was 61.4 (range: 24-132) months. Five patients underwent subsequent surgery because of refractory abdominal pain after endotherapy. Of the remaining 37 patients who received therapeutic ERCP alone, abdominal pain improved in 30 (81.1%) patients, and was completely relieved in 24 (64.9%) patients during the period of follow-up.CONCLUSIONS: Therapeutic ERCP may offer long-term improvement in pain in children and adolescents with CP.