Medication dosing in outpatients with heart failure after implementation of a practice-based performance improvement intervention: findings from IMPROVE HF.
Medication dosing in outpatients with heart failure after implementation of a practice-based performance improvement intervention: findings from IMPROVE HF.
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DOI：
10.1111/j.1751-7133.2011.00250.x
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Fonarow, Gregg C
中科院分区：
文献类型：
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作者：
Gheorghiade, Mihai;Albert, Nancy M;Fonarow, Gregg C
符合条件的患有心力衰竭 (HF) 和左心室射血分数 (LVEF) 降低的门诊患者通常不会接受目标剂量的心力衰竭药物治疗。改善门诊循证心力衰竭治疗使用登记处 (IMPROVE HF) 评估了基于实践的性能改善干预措施对 LVEF ≤ 35% 门诊患者治疗的效果。在基线和 24 个月时收集血管紧张素转换酶 (ACE) 抑制剂/血管紧张素受体阻滞剂 (ARB)、β-阻滞剂和醛固酮拮抗剂的具体药物和剂量。分析了每种药物类别的剂量随时间的变化。 7605 名患者的数据可用。基线时，目标剂量治疗率分别为 36.1%、20.5% 和 74.4%。绝对和相对改善分别为 9.8% 和 47.7% ( P
Eligible outpatients with heart failure (HF) and reduced left ventricular ejection fraction (LVEF) frequently do not receive target doses of HF medications. The Registry to Improve the Use of Evidence-Based Heart Failure Therapies in the Outpatient Setting (IMPROVE HF) evaluated the effect of a practice-based performance improvement intervention on treatment of outpatients with LVEF ≤35%. Specific agent and dose were collected at baseline and 24months for angiotensin-converting enzyme (ACE) inhibitors/angiotensin receptor blockers (ARBs), beta-blockers, and aldosterone antagonists. Changes in dosing over time were analyzed for each medication class. Data were available for 7605 patients. At baseline, target dose treatment rates were 36.1%, 20.5%, and 74.4%, respectively. Absolute and relative improvements of 9.8% and 47.7% ( P