Cooling is a potent vasodilator of deep vessels in the rat.
Cooling is a potent vasodilator of deep vessels in the rat.
复制标题
冷却是大鼠深层血管的有效血管扩张剂。
DOI：
--
复制
发表时间：
2001
影响因子：
2.1
通讯作者：
O. Thulesius
中科院分区：
文献类型：
--
作者：
S. Mustafa;O. Thulesius
本研究的目的是确定冷却对肺动脉和主动脉平滑肌张力的影响，并阐明这些反应的基本机制。我们记录了器官浴中逐步冷却大鼠肺动脉和主动脉平滑肌条的等长张力。在加入各种干扰已知神经源性（自主神经阻滞剂、河豚毒素）和肌源性机制（钙通道阻滞剂）的标准药物之前和之后，测试了冷却反应。我们还检验了存在冷却释放物质的假设。逐步冷却（37℃至4℃）主动脉平滑肌诱导可重复的分级松弛，与温度成反比。冷却诱导的松弛不依赖于神经机制，也不依赖于神经递质或冷却释放物质（如NO或CO）的释放。肺动脉和主动脉平滑肌制剂的冷却诱导了与冷却温度成反比的分级肌原性松弛。该机制不依赖于局部神经或已知介质，而是与冷却的直接物理化学作用有关。
The objectives of this study were to determine the effect of cooling on smooth muscle tone of the pulmonary artery and aorta and to clarify the basic mechanism of these responses. We recorded isometric tension in smooth muscle strips of rat pulmonary artery and aorta in organ baths during stepwise cooling. Cooling responses were tested before and after the addition of various standard agents that interfere with known neurogenic (autonomic blockers, tetrodotoxin) and myogenic mechanisms (calcium channel blockers) of relaxation. We also examined the hypothesis of the presence of a cooling-released substance. Stepwise cooling (37degrees C to 4 degrees C) of aortic smooth muscle induced reproducible graded relaxations that were inversely proportional to temperature. Cooling-induced relaxation was not dependent on a neural mechanism nor the release of neurotransmitters or a cooling-released substance such as NO or CO. Cooling of pulmonary arterial and aortic smooth muscle preparations induced a graded myogenic relaxation inversely proportional to the cooling temperature. The mechanism is not dependent on local nervous or known mediators but related to a direct physico-chemical effect of cooling.
影响因子：
--
作者：
FABER, JE
通讯作者：
FABER, JE