Effects of skeletal morbidities on longitudinal patient-reported outcomes and survival in patients with metastatic prostate cancer
Effects of skeletal morbidities on longitudinal patient-reported outcomes and survival in patients with metastatic prostate cancer
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DOI：
10.1007/s00520-006-0203-x
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发表时间：
2007-07-01
影响因子：
3.1
通讯作者：
Saad, Fred
中科院分区：
文献类型：
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作者：
DePuy, Venita;Anstrom, Kevin J.;Saad, Fred
工作目标：患有骨转移的前列腺癌患者经常会因疾病而出现骨骼疾病。我们试图量化对患者报告的骨骼相关事件 (SRE) 结果的纵向影响，并确定经历过 SRE 的患者健康相关生活质量 (HRQOL) 和疼痛的下降情况。材料和方法：数据来自一项治疗与晚期前列腺癌骨转移相关的 SRE 的临床试验。结果测量包括癌症治疗一般功能评估 (FACT-G) 和简短疼痛量表。在随机化后 6 个月存活的患者中，随机化后最初 6 个月内没有 SRE 的患者通过倾向评分与经历一种或多种 SRE 的患者进行匹配。同样，将患有一种 SRE 的患者与患有两种或两种以上 SRE 的患者子集相匹配。主要结果：初始阶段患有 SRE 的患者的生存率和 HRQOL 显着低于那些没有 SRE 的患者。疼痛差异、FACT-G 总分以及 FACT-G 身体、情绪和功能分量表之间存在显着差异。具有单个和多个 SRE 的患者的比较显示出相似的模式。结论：SRE 的存在与该患者群体中较差的生存率和较差的 HRQOL 显着相关。 SRE 强度的增加显示了生存率日益下降和 HRQOL 较差的模式。
Goals of work: Patients with prostate cancer metastasized to bone frequently experience skeletal morbidities as a result of their disease. We sought to quantify the longitudinal effects on patient-reported outcomes of skeletal-related events (SREs) and to ascertain the declines in health-related quality of life (HRQOL) and pain experienced by patients who experienced SREs.Materials and methods: Data are from a clinical trial for the treatment of SREs associated with advanced prostate cancer metastatic to bone. Outcome measures included the Functional Assessment of Cancer Therapy-General (FACT-G) and the Brief Pain Inventory. Among patients who survived 6 months after randomization, patients with no SREs in the initial 6 months after randomization were matched via propensity scores with those experiencing one or more SREs. Similarly, patients with one SRE were matched with a subset of patients with two or more SREs.Main results: Patients with SREs in the initial period had significantly worse survival and HRQOL than those with no SREs. Significant differences were found between the pain differences, FACT-G total scores, and FACT-G physical, emotional, and functional subscales. Comparisons of patients with single vs multiple SREs showed similar patterns.Conclusions.: The presence of SREs is significantly associated with worse survival and poorer HRQOL in this patient population. Increasing SRE intensity shows a pattern of increasingly decreased survival and poorer HRQOL.