Age-specific questionnaires distinguish GERD symptom frequency and severity in infants and young children: Development and initial validation
Age-specific questionnaires distinguish GERD symptom frequency and severity in infants and young children: Development and initial validation
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DOI：
10.1097/01.mpg.0000172885.77795.0f
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发表时间：
2005-08-01
影响因子：
2.9
通讯作者：
Fitzgerald, JF
中科院分区：
文献类型：
--
作者：
Deal, L;Gold, TD;Fitzgerald, JF
在一项在有和无GERD临床诊断的婴儿（1 - 11个月）和幼儿（1 - 4岁）中进行的试点研究中，开发并前瞻性测试了两份胃食管反流病（GERD）症状问卷。一名儿科胃肠病学家作出GERD的临床诊断。4个研究中心的父母或监护人完成了问卷调查，提供了2个年龄队列的症状频率和严重程度信息。在婴儿中，评估的症状包括背部痉挛、窒息或作呕、打嗝、易怒、拒绝进食和呕吐或反胃。在幼儿中，评估的症状包括腹痛、打嗝或嗳气、进食时窒息、吞咽困难、拒绝进食和呕吐或反胃。受访者被要求描述其他症状。症状频率是在完成问卷前7天内每种症状的发生次数。症状严重程度从1（根本不严重）至7（最严重）。个体症状评分计算为症状频率和严重程度评分的乘积。综合症状评分是个体症状评分的总和。GERD患儿的平均综合症状评分和单项症状评分均高于对照组（分别为P < 0.001和P < 0.05），且婴幼儿组高于对照组（分别为P < 0.001和P < 0.05）。呕吐/反流在GERD婴儿中尤其普遍（90%）。两组GERD患者更有可能出现更严重的症状。我们发现GERD症状问卷有助于区分有症状的GERD婴幼儿和健康儿童。
Two gastroesophageal reflux disease (GERD) symptom questionnaires were developed and tested prospectively in a pilot study conducted in infants (1 through 11 months) and young children (1 through 4 years) with and without a clinical diagnosis of GERD. A pediatric gastroenterologist made the clinical diagnosis of GERD. Parents or guardians at 4 study sites completed the questionnaires, providing information on the frequency and severity of symptoms appropriate to the 2 age cohorts. In infants, symptoms assessed were back arching, choking or gagging, hiccups, irritability, refusal to feed and vomiting or regurgitation. In young children, symptoms assessed were abdominal pain, burping or belching, choking when eating, difficulty swallowing, refusal to eat and vomiting or regurgitation. Respondents were asked to describe additional symptoms. Symptom frequency was the number of occurrences of each symptom in the 7 days before completion of the questionnaire. Symptom severity was rated from 1 (not at all severe) to 7 (most severe). An individual symptom score was calculated as the product of symptom frequency and severity scores. The composite symptom score was the sum of the individual symptom scores. The mean composite symptom and individual symptom scores were higher in infants (P < 0.001 and P < 0.05, respectively) and young children (P < 0.001 and P < 0.05, respectively) with GERD than controls. Vomiting/regurgitation was particularly prevalent in infants with GERD (90%). Both groups with GERD were more likely to experience greater severity of symptoms. We found the GERD Symptom Questionnaire useful in distinguishing infants and young children with symptomatic GERD from healthy children.