Hydrodynamically Driven Self-Assembly of Giant Vesicles of Metal Nanoparticles for Remote-Controlled Release
Hydrodynamically Driven Self-Assembly of Giant Vesicles of Metal Nanoparticles for Remote-Controlled Release
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DOI：
10.1002/anie.201208425
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发表时间：
2013-01-01
影响因子：
16.6
通讯作者：
Nie, Zhihong
中科院分区：
文献类型：
--
作者：
He, Jie;Wei, Zengjiang;Nie, Zhihong
分子两亲物（例如，表面活性剂或两亲嵌段共聚物（BCP））自组装成囊泡模拟由脂质双层组成的生物膜的构造。[1]这些囊泡，即脂质体或聚合物囊泡，由于其在药物递送，[2]生物传感，[3]和催化中的吸引人的应用而受到相当大的关注。[4]将无机纳米颗粒（NP）掺入囊泡膜中可以赋予它们先进的功能（例如，等离子体，磁性和发光特性）[5]，同时保留有机成分的良好特性。具有固有刚性的NP的存在也可以显著地延长囊泡的弹性模量，从而提供优于其有机对应物的机械优势。[6]近年来，聚合物系链的两亲性纳米粒子作为一类新型的纳米级胶体结构单元在功能材料的制备中受到了广泛的关注。[5c-f类似于分子两亲物，这些材料合并了聚合物和无机NP的性质以组织成广泛的纳米结构，包括胶束、囊泡、线和小管。[5c-f，7]
Self-assembly of molecular amphiphiles (for example, surfactants or amphiphilic block copolymers (BCPs)) into vesicles mimics the construction of biological membranes composed of lipid bilayers.[1] These vesicles, namely liposomes or polymersomes, have received considerable attention owing to their appealing applications in drug delivery,[2] biosensing,[3] and catalysis.[4] The incorporation of inorganic nanoparticles (NPs) into vesicular membranes can endow them with advanced functionalities (for example, plasmonic, magnetic, and luminescent properties)[5] while preserving the well-established properties of organic components. The presence of NPs with inherent rigidity can also significantly extend the elastic modulus of vesicles, thus offering mechanical advantages over their organic counterparts.[6] Recently, polymer-tethered amphiphilic NPs have received considerable attention as a new class of nanoscale colloidal building blocks for fabricating functional materials.[5c–f, 7] Resembling molecular amphiphiles, these materials merge the nature of polymers and inorganic NPs to organize into a wide range of nanostructures, including micelles, vesicles, wires, and tubules.[5c–f, 7]