The association of the progression of knee osteoarthritis with high-sensitivity CRP in community-dwelling people?the Yakumo study
The association of the progression of knee osteoarthritis with high-sensitivity CRP in community-dwelling people?the Yakumo study
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社区居民膝骨关节炎进展与高敏 CRP 的关联？Yakumo 研究
DOI：
10.1007/s10067-020-05541-2
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发表时间：
2021
影响因子：
3.4
通讯作者：
Imagama Shiro
中科院分区：
文献类型：
--
作者：
Kondo Fumiki;Takegami Yasuhiko;Ishizuka Shinya;Hasegawa Yukiharu;Imagama Shiro
我们的目的是调查高敏C反应蛋白（hs-CRP）水平和膝关节骨关节炎（KOA）的状态之间的关系，以及是否高hs-CRP水平预测临床KOA的进展，在社区居住people.MethodsWe招募了247名受试者（男性，n= 99;女性，n= 148）谁参加了“八云研究”至少两次，从2003年至2008年。使用膝关节骨关节炎计算机辅助诊断（KOACAD）测量系统通过膝关节X线片评估KOA，以获得mJSW、骨赘面积（OPA）和股胫角（FTA）。使用视觉模拟量表（VAS，0-100）测量膝关节疼痛强度。首先，我们进行了多元回归分析，以评估初始hs-CRP与mJSW、OPA、FTA和VAS之间的关系。其次，我们检查了hs-CRP变化量与放射学进展和VAS变化之间的相关系数。第三，我们分成两组。H组hs-CRP水平升高（> 0.1mg/dl）。我们根据BMI、年龄、性别和基线时的内侧mJSW以1：1的比例挑选与H组匹配的受试者;这些参与者被归类为对照组（L组）。统计学分析采用Mann-Whitney U检验，P < 0.05为有统计学意义。结果多元回归分析显示，初始hs-CRP是mJSW和VAS变化的显著解释因素。VAS值变化与hs-CRP变化呈负相关。此外，hs-CRP的变化与放射学改变无相关性。在这些受试者中，55例hs-CRP水平升高（> 0.1 mg/dl）（H组）。在hs-CRP水平≤ 0.1 mg/dl的192例受试者中，根据年龄、性别、BMI和基线时平均最小关节间隙宽度（mJSW）将55例受试者与H组患者匹配，并用作对照组（L组）。H组内侧mJSW的狭窄程度和OPA的变化量明显大于L组。FTA和VAS评分的变化量在两组之间没有差异。ConclusionHs-CRP水平与膝关节骨性关节炎的进展显著相关。Key Points·我们调查了hs-CRP水平与膝关节骨性关节炎的进展和疼痛之间的关系。·我们使用KOACAD系统，该系统可以自动测量平片中的内侧和外侧关节间隙狭窄、骨赘和股骨-胫骨角度。·hs-CRP水平与膝关节骨性关节炎的进展显著相关。
ObjectiveWe aimed to investigate the relationship between high-sensitivity CRP (hs-CRP) levels and the knee osteoarthritis (KOA) status and whether high hs-CRP levels predict the progression of clinical KOA in community-dwelling people.MethodsWe enrolled 247 subjects (male,n= 99; female,n= 148) who participated in the “Yakumo study” at least twice from 2003 to 2008. The KOA was evaluated by knee X-ray using the knee osteoarthritis computer-aided diagnosis (KOACAD) measurement system to obtain the mJSW, the size of the osteophyte area (OPA), and femorotibial angle (FTA). The pain intensity of the knee joint was measured using a visual analog scale (VAS, 0–100). First, we performed a multiple regression analysis to assess the relationship between the initial hs-CRP and mJSW, OPA, FTA, and VAS. Second, we examined the correlated coefficients between the amount of change hs-CRP and radiographic progressions and VAS changes. Third, we divided into two groups. Group H elevated hs-CRP levels (> 0.1 mg/dl). We picked up the subject matched to Group H according to BMI, age, sex, and medial mJSW at baseline in a 1:1 ratio; these participants were classified as the control group (Group L). The Mann-Whitney U test was used to compare the demographic data between the two groups.Pvalues of < 0.05 were considered to indicate statistical significance.ResultsThe initial hs-CRP was a significant explanatory factor for mJSW and VAS change in multiple regression analysis. The change of VAS value negatively correlated with the change of hs-CRP. Besides, the change of hs-CRP did not correlate with the radiographical change. Among these subjects, 55 had elevated hs-CRP levels (> 0.1 mg/dl) (Group H). Among the 192 subjects whose hs-CRP levels were ≤ 0.1 mg/dl, 55 subjects were matched to patients in Group H according to the age, sex, BMI, and average minimum joint space width (mJSW) at baseline and were used as a control group (Group L). The narrowing of the medial mJSW and the amount of change in OPA in group H were significantly greater than group L. The amount of change in FTA and VAS scores did not differ between the two groups.ConclusionHs-CRP levels would be significantly associated with the progression of knee osteoarthritis.Key Points•We investigated the relationship between hs-CRP levels and the progression and the pain of osteoarthritis knee.•We used a KOACAD system, which can measure the medial and lateral joint space narrowing, osteophyte, and femoral-tibia angle from plain radiographs automatically.•Hs-CRP levels were significantly associated with the progression of knee osteoarthritis.