Noise exposure at young age impairs the auditory object exploration behavior of rats in adulthood
Noise exposure at young age impairs the auditory object exploration behavior of rats in adulthood
复制标题
幼年时期的噪声暴露会损害成年大鼠的听觉物体探索行为
DOI：
10.1016/j.physbeh.2008.06.005
复制
发表时间：
2008-09-03
影响因子：
2.9
通讯作者：
Sun, Xinde
中科院分区：
文献类型：
--
作者：
Zhang, Jiping;Chen, Liang;Sun, Xinde
环境噪声在我们的日常生活中无处不在。本研究的目的是通过比较三组大鼠在水迷宫中定位声源的能力来确定出生后暴露于中等水平噪声对成年大鼠听觉物体探索行为的影响。将听力发育关键期和成年期两组大鼠暴露于80 dB SPL间断白色噪声中，每天8 h，连续2周。对照组大鼠不暴露于噪声。从出生后第77天开始测试大鼠在水迷宫中定位位于声源附近的隐藏平台的能力。在训练过程中观察到控制大鼠和暴露于噪声的大鼠在成年期的性能的持续改善，而暴露于噪声的大鼠在年轻时表现出显着较差的性能。这些结果表明，长期暴露于中等水平的噪声的年轻大鼠造成显着损害的听觉对象的探索行为相比，成年动物暴露于相同的中等水平的噪声。(c)2008年爱思唯尔公司All rights reserved.
Environment noise is ubiquitous in our daily life. The aim of the present study was to determine the effect of postnatal exposure to moderate-level noise on the auditory object exploration behavior of adult rats by comparing the ability of three groups of rats to locate a sound source in a water maze. Two groups of rats, either in the critical period of hearing development or in adulthood, were exposed to 80 dB SPL interrupted white noise for 8 h per day for two weeks. The control group of rats was not exposed to the noise. The ability of the rats to locate a hidden platform that was situated near a sound source in a water maze was tested starting on postnatal day 77. A continuous improvement in the performance of control rats and rats exposed to noise in adulthood was observed during training, whereas rats exposed to noise at a young age exhibited a significantly worse performance. These findings indicated that long-term exposure of young rats to moderate-level noise caused significant impairment of their auditory object exploration behavior compared to exposure of adult animals to the same moderate-level noise. (c) 2008 Elsevier Inc. All rights reserved.