Cell biological factors in ductal carcinoma in situ (DCIS) of the breast-relationship to ipsilateral local recurrence and histopathological characteristics
Cell biological factors in ductal carcinoma in situ (DCIS) of the breast-relationship to ipsilateral local recurrence and histopathological characteristics
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DOI：
10.1016/s0959-8049(01)00165-4
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发表时间：
2001-08-01
影响因子：
8.4
通讯作者：
Fernö, M
中科院分区：
文献类型：
--
作者：
Ringberg, A;Anagnostaki, L;Fernö, M
1987年至1991年在瑞典南部卫生保健区诊断的导管原位癌（DCIS）的所有病例，并进行保乳治疗（BCT）（n = 66）或不（n = 121）术后放疗（RT），进行临床随访，形态学重新评估和细胞生物学因素（免疫组化测定或DNA流式细胞术）分析。诊断时的中位年龄为58岁（范围29-83岁），中位随访时间为62个月。雌激素（ER）和孕激素受体（PR）阴性、c-erbB-2过表达、bcl-2低表达、p53积聚、DNA非二倍体和高Ki-67与高级别DCIS和粉刺型坏死密切相关。相反，仅c-erbB-2和PgR与生长模式（非弥漫性与弥漫性）有显著相关性。细胞生物学因子之间也存在很强的相关性，并引入了基于主成分分析的概括细胞生物学指数（CBI-7）。在未接受术后RT的组中，31例发生同侧局部复发（13例浸润性，18例DCIS）。在单变量分析中，与p53正常、Ki 67低和bcl-2高的患者相比，p53蓄积、Ki 67高或bcl-2低的患者的同侧无复发间期（IL-RFI）显著或几乎显著较短。其余细胞生物学因素的预后重要性不太明显。另一方面，CBI-7指数是复发的强预测因子。(C)2001爱思唯尔科技有限公司版权所有。
All cases of ductal carcinoma in situ (DCIS) diagnosed from 1987 to 1991 in the Southern Health Care Region of Sweden, and operated upon with breast conserving treatment (BCT) with (n = 66) or without (n = 121) postoperative radiation (RT) were clinically followed, morphologically re-evaluated and analysed for cell biological factors (immunohistochemical assays or DNA flow cytometry). Median age at diagnosis was 58 years (range 29-83 years) and median follow-up was 62 months. Oestrogen (ER)- and progesterone receptor (PR)-negativity, c-erbB-2 overexpression, low bcl-2 expression, p53 accumulation, DNA non-diploidy and high Ki67, were strongly associated with high grade DCIS, and comedo-type necrosis. In contrast, significant associations to growth pattern (not diffuse versus diffuse) were seen only for c-erbB-2 and PgR. There was also a strong relationship between the cell biological factors, and a summary cell biological index based on principal component analysis was introduced (CBI-7). In the group that had not received postoperative RT, 31 ipsilateral local recurrences occurred (13 invasive, 18 DCIS). Ipsilateral recurrence-free interval (IL-RFI) was in univariate analyses significantly, or almost significantly, shorter for patients showing p53 accumulation, high Ki67 or low bcl-2, compared with patients with normal p53, low Ki67 and high bcl-2. The prognostic importance of the remaining cell biological factors was less pronounced. On the other hand, the index CBI-7, was a strong predictor for recurrence. (C) 2001 Elsevier Science Ltd. All rights reserved.