Antibacterial prenylflavone derivatives from Psoralea corylifolia, and their structure-activity relationship study
Antibacterial prenylflavone derivatives from Psoralea corylifolia, and their structure-activity relationship study
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DOI：
10.1016/j.bmc.2004.06.014
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发表时间：
2004-08-15
影响因子：
3.5
通讯作者：
Yue, JM
中科院分区：
文献类型：
--
作者：
Yin, S;Fan, CQ;Yue, JM
本文报道了3个新的异戊烯基黄酮类化合物，即corylifolsA-C（1-3），以及13个已知化合物。通过1D和2D NMR等波谱技术鉴定了它们的结构。对分离菌株进行了抗菌活性测定，其中9株对金黄色葡萄球菌和葡萄球菌有较强的抗菌活性。表皮并对异戊二烯基黄酮类化合物（1-16）的抑菌构效关系进行了初步探讨。(C)2004爱思唯尔有限公司保留所有权利。
Three new prenylflavonoids, namely corylifols A-C (1-3), together with 13 known ones, were isolated from the seeds of Psoralea corylifolia. Their structures were elucidated by spectral methods including 1D and 2D NMR techniques. All the isolates were tested on antibacterial assays, and nine of them showed significant antibacterial activities against two pathogenic bacteria Staphylococcus aureus and S. epidermidis. The antibacterial structure-activity relationship of these prenylflavonoids (1-16) was also briefly discussed. (C) 2004 Elsevier Ltd. All rights reserved.