Stability of Ti3C2Tx MXene Films and Devices under Clinical Sterilization Processes.
Stability of Ti3C2Tx MXene Films and Devices under Clinical Sterilization Processes.
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DOI：
10.1021/acsnano.3c01525
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发表时间：
2023-05
期刊：
影响因子：
17.1
通讯作者：
Spencer Averbeck;Doris Xu;Brendan B. Murphy;Kateryna Shevchuk;S. Shankar;Mark Anayee;Marcelo Der Torossian Torres;Michael S Beauchamp;César de la Fuente-Nunez;Y. Gogotsi;Flavia Vitale
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文献类型：
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作者：
Spencer Averbeck;Doris Xu;Brendan B. Murphy;Kateryna Shevchuk;S. Shankar;Mark Anayee;Marcelo Der Torossian Torres;Michael S Beauchamp;César de la Fuente-Nunez;Y. Gogotsi;Flavia Vitale
MXene 在生物医学研究中得到广泛研究，其应用范围从再生医学到生物电子学。然而，为了能够采用 MXene 并将其集成到治疗平台和设备中，必须确定其在标准灭菌程序下的稳定性。在这里，我们全面研究了常见热（高压灭菌器）和化学（环氧乙烷 (EtO) 和 H2O2 气体等离子体）灭菌方案对薄膜 Ti3C2TX MXene 微电极和由 Ti3C2TX 注入纤维素弹性体复合材料制成的介观阵列的电气、化学、结构和机械效应。我们还评估了灭菌过程在消除 Ti3C2TX 薄膜和复合材料中所有病原体方面的有效性。灭菌后分析表明，高压灭菌器和 EtO 不会改变 Ti3C2TX 的直流电导率、电化学阻抗、表面形态或晶体结构，并且都能有效消除两种类型的 Ti3C2TX 设备中的大肠杆菌。另一方面，暴露于 H2O2 气体等离子体灭菌 45 分钟会导致 Ti3C2TX 薄膜和复合材料的结构和性能严重退化。 Ti3C2Tx 在 EtO 和高压灭菌后的稳定性以及病原体的完全去除确立了基于 Ti3C2Tx 的技术的两种灭菌工艺的可行性。
MXenes are being heavily investigated in biomedical research, with applications ranging from regenerative medicine to bioelectronics. To enable the adoption and integration of MXenes into therapeutic platforms and devices, however, their stability under standard sterilization procedures must be established. Here, we present a comprehensive investigation of the electrical, chemical, structural, and mechanical effects of common thermal (autoclave) and chemical (ethylene oxide (EtO) and H2O2 gas plasma) sterilization protocols on both thin-film Ti3C2Tx MXene microelectrodes and mesoscale arrays made from Ti3C2Tx-infused cellulose-elastomer composites. We also evaluate the effectiveness of the sterilization processes in eliminating all pathogens from the Ti3C2Tx films and composites. Post-sterilization analysis revealed that autoclave and EtO did not alter the DC conductivity, electrochemical impedance, surface morphology, or crystallographic structure of Ti3C2Tx and were both effective at eliminating E. coli from both types of Ti3C2Tx-based devices. On the other end, exposure to H2O2 gas plasma sterilization for 45 min induced severe degradation of the structure and properties of Ti3C2Tx films and composites. The stability of the Ti3C2Tx after EtO and autoclave sterilization and the complete removal of pathogens establish the viability of both sterilization processes for Ti3C2Tx-based technologies.