"Normal" liver stiffness measure (LSM) values are higher in both lean and obese individuals: A population-based study from a developing country
"Normal" liver stiffness measure (LSM) values are higher in both lean and obese individuals: A population-based study from a developing country
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DOI：
10.1002/hep.24694
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发表时间：
2012-02-01
期刊：
影响因子：
13.5
通讯作者：
Chowdhury, Abhijit
中科院分区：
文献类型：
--
作者：
Das, Kausik;Sarkar, Rajib;Chowdhury, Abhijit
肝脏硬度测量（LSM）需要在种族和人体测量不同的健康受试者中进行探索（以得出一个可接受的正常范围），也需要在肝病患者中进行研究。鉴于这一目标，使用纤维扫描的瞬时弹性成像（TE）对437名谷丙转氨酶（ALT）水平正常的健康受试者进行了LSM，这些受试者来自birbham人口项目（BIRPOP）的自由生活人群。来自消化和肝脏疾病学院（SDLD；研究生医学教育与研究所[IPGME&R]，加尔各答，印度）肝病学诊所的274例肝病患者，其中188例为非酒精性脂肪性肝病（NAFLD）， 86例为病毒性和其他病因的慢性肝炎。125例患者行肝活检。LSM的正常值范围（以健康受试者的第5和第95百分位值定义）分别为3.2和8.5 kPa。身体质量指数(BMI; <
The liver stiffness measure (LSM) needs to be explored in ethnically and anthropometrically diverse healthy subjects (to derive an acceptable normal range) and also in patients with liver disease. In view of this objective, LSM was performed by transient elastography (TE) using FibroScan in 437 healthy subjects with normal alanine aminotransferase (ALT) levels, recruited from a free-living population of the Birbhum Population Project (BIRPOP; ), a Health and Demographic Surveillance System (HDSS), and from 274 patients with liver disease attending the Hepatology Clinic of the School of Digestive and Liver Diseases (SDLD; Institute of Post Graduate Medical Education & Research [IPGME&R], Kolkata, India) including 188 with nonalcoholic fatty liver disease (NAFLD) and 86 with chronic hepatitis of viral and other etiologies. Liver biopsy was performed in 125 patients. The range of normal values for LSM, defined by 5th and 95th percentile values in healthy subjects, was 3.2 and 8.5 kPa, respectively. Healthy subjects with a lower body mass index (BMI; <