The intracellular phospholipase A1 protein family
The intracellular phospholipase A1 protein family
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DOI：
10.1515/bmc-2012-0014
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发表时间：
2012-10
期刊：
影响因子：
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通讯作者：
K. Tani;Takeshi Kogure;H. Inoue
中科院分区：
文献类型：
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作者：
K. Tani;Takeshi Kogure;H. Inoue
摘要磷脂酶A1是一种水解磷脂，产生2-酰基溶血磷脂和脂肪酸的酶。细胞内磷脂酶A1（iPLA 1）蛋白家族是最近发现的一个相对较新的脂质代谢酶家族。低等真核生物（如酵母和线虫）和植物只有一种iPLA 1蛋白，而哺乳动物有三种iPLA 1家族蛋白（PA-PLA 1/DDHD 1/iPLA 1 α，p125/Sec 23 IP/iPLA 1 β和KIAA 0725 p/DDHD 2/iPLA 1 γ）。哺乳动物iPLA 1蛋白定位于不同的细胞区室，其中两个，p125和KIAA 0725 p，已经涉及膜运输事件。最近对几种生物的基因打靶研究表明，iPLA 1家族蛋白参与多种生理功能，包括植物茎向重力性、上皮干细胞分化和精子发生。本文综述了iPLA 1家族蛋白的特点及其生理功能的研究进展。
Abstract Phospholipase A1 is an enzyme that hydrolyzes phospholipids, producing 2-acyl-lysophospholipids and fatty acids. The intracellular phospholipase A1 (iPLA1) protein family is a relatively recently discovered lipid-metabolizing enzyme family. Lower eukaryotes, such as yeasts and nematodes, and plants have only one iPLA1 protein, whereas mammals have three iPLA1 family proteins (PA-PLA1/DDHD1/iPLA1α, p125/Sec23IP/iPLA1β and KIAA0725p/DDHD2/iPLA1γ). Mammalian iPLA1 proteins are localized in different cellular compartments, and two of them, p125 and KIAA0725p, have been implicated in membrane trafficking events. Recent gene targeting studies on several organisms showed that iPLA1 family proteins are involved in various physiological functions, including plant shoot gravitropism, epithelial stem cell differentiation and spermiogenesis. In this review, we describe the features of iPLA1 family proteins and recent progress regarding our understanding of their physiological functions.