Detection of point mutations in rpoB gene of rifampin-resistant Rickettsia typhi.

Detection of point mutations in rpoB gene of rifampin-resistant Rickettsia typhi.
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耐利福平伤寒立克次体rpoB基因点突变的检测

DOI:
10.1128/aac.42.7.1845
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发表时间:
1998
影响因子:
4.9
通讯作者:
Azad,AF
Azad,AF
中科院分区:
医学2区
文献类型:
--
作者:
Troyer,JM;Radulovic,S;Andersson,SG;Azad,AF

文献摘要

相似文献

利福平耐药伤寒锥虫(Rif突变体)与野生型的热基因分析。对伤寒进行了测序和比较。突变核糖核酸(Rif mutantrepob)有三个核苷酸取代,导致残基151,201和271的氨基酸发生变化,这可能是利福平耐药的基础。
TherpoBgene of rifampin-resistantRickettsia typhi(Rif mutant) and wild-typeR. typhiwere sequenced and compared. The Rif mutantrpoBhad three nucleotide substitutions, which resulted in amino acid changes at residues 151, 201, and 271 and may be the basis for the rifampin resistance.