Use of proton nmr spectroscopy to measure propofol metabolites in the urine of the female Caucasian patient.
Use of proton nmr spectroscopy to measure propofol metabolites in the urine of the female Caucasian patient.
复制标题
使用质子核磁共振光谱法测量白人女性患者尿液中的丙泊酚代谢物。
DOI：
10.3109/00498259409043299
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
B. Wright
中科院分区：
文献类型：
--
作者：
J. Sneyd;P. Simons;B. Wright
1. Six female Caucasian patients received i.v. doses of propofol (2.7 +/- 0.3 (SE) mg/kg) for induction of anaesthesia. Anaesthesia was maintained with nitrous oxide, oxygen and enflurane for periods up to 3 h. A total urine collection was made from each subject for 24 h after administration of propofol; samples were concentrated and analysed for propofol metabolites by nmr spectroscopy. 2. By 24 h, 50.9 +/- 4.0% of the dose of propofol was recovered as metabolites. The proportions of propofol metabolites, 1-quinol glucuronide (1-QG), 4-quinol glucuronide (4-QG), propofol glucuronide (PG) and 4-quinol sulphate (4-QS) recovered in urine (0-24 h) of the patients were 12 +/- 1, 8 +/- 2, 76 +/- 4 and 4 +/- 1% respectively. However, one patient showed a metabolite profile in which PG comprised 93% and 1-QG 7% of the total metabolites. 3. Nmr spectroscopy has been shown to be a satisfactory method for the quantification of propofol metabolites in urine without the necessity for reference samples.
