Up-to-date membrane biogenesis in the autophagosome formation
Up-to-date membrane biogenesis in the autophagosome formation
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DOI：
10.1016/j.ceb.2013.03.004
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发表时间：
2013-08-01
影响因子：
7.5
通讯作者：
Yoshimori, Tamotsu
中科院分区：
文献类型：
--
作者：
Hamasaki, Maho;Shibutani, Shusaku T.;Yoshimori, Tamotsu
当细胞处于饥饿状态，受到细菌等异物的入侵，并含有受损的细胞器或聚集的蛋白质时，细胞质内形成称为自噬体的双膜细胞器，将这些物质包围、分离并传递给溶酶体进行降解。这种途径被称为“自噬”，从酵母到哺乳动物细胞都是保守的。与其他细胞器不同，自噬体是从头形成的，因此对其膜生物发生提出了独特的问题。在这里，我们重点介绍了一些与自噬体形成有关的最新发现，以及源自其他细胞器的自噬特异性囊泡的可能参与，但特别关注自噬体的形成位点和自噬体与其他细胞器的关系。
When cells are starved, are invaded by foreign bodies such as bacteria, and contain damaged organelles or aggregated proteins, double-membrane organelles called autophagosomes are formed within the cytoplasm to surround, isolate and deliver these materials to lysosomes for degradation. This pathway, called 'autophagy', is conserved from yeast to mammalian cells. Unlike other organelles, the autophagosome forms de novo, thus raising unique questions regarding its membrane biogenesis. Here we highlight a number of recent findings related to autophagosome formation and possible involvement of autophagy-specific vesicles originating from other organelles, but with particular attention on the formation sites and the relationship of the autophagosome to other organelles.