Left atrial pressure in normotensive and spontaneously hypertensive rats.
Left atrial pressure in normotensive and spontaneously hypertensive rats.
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正常血压和自发性高血压大鼠的左心房压力。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
P. Thoren
中科院分区：
文献类型：
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作者：
E. Noresson;S. Ricksten;P. Thoren
采用慢性植入导管测量成年冈本系自发性高血压大鼠（SHR）和正常血压对照大鼠（NCR）的左心房压。SHR患者临终时左房压（10.3 +/- 0.4 mmHg）是NCR患者（4.6 +/- 0.3 mmHg）的两倍多。两组大鼠胸膜内压无差异，因此SHR左房压升高代表其左心室舒张充盈压升高。这被认为是对早期报道的SHR中Frank-Starling曲线右移的最重要补偿（Hallbäck, Isaksson & Noresson 1975, Noresson et al. 1979a）。如果没有这种补偿，肥厚心脏的中风量就会大大减少。
The left atrial pressure in adult spontaneously hypertensive rats (SHR) of the Okamoto strain and normotensive control rat (NCR) was measured via chronically implanted catheters. In SHR left atrial pressure in end-expiration was more than twice as high (10.3 +/- 0.4 mmHg) as in NCR (4.6 +/- 0.3 mmHg). There was no difference in the intrapleural pressure between the two groups of rats, therefore the enhanced left atrial pressure in SHR represents a real rise in the diastolic filling pressure of its left ventricle. This is considered to be the most important compensation for the earlier reported rightward shift of the Frank-Starling curve in SHR (Hallbäck, Isaksson & Noresson 1975, Noresson et al. 1979a). Without this compensation the stroke volume would have been drastically reduced for the hypertrophied heart.