Epidemiology and control of ascariasis in Korea.
Epidemiology and control of ascariasis in Korea.
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DOI：
10.3347/kjp.1990.28.suppl.49
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发表时间：
1990-12
期刊：
影响因子：
--
通讯作者：
B. Seo
中科院分区：
文献类型：
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作者：
B. Seo
鉴于流行病学和控制策略，特别参考韩国过去几年获得的数据，对蛔虫病进行了回顾。蝾螈体长范围为雌性12.5-13.5厘米、1.8-2.1个月，雄性为10.5-11.5厘米、2.1-2.5个月。在每例1只雌虫中，产卵能力从体长12.6厘米稳定增加到25.0厘米，然后在体长到27.5厘米后显着下降。分析排卵模式，发现有6条或更多蠕虫的病例不可能是假阴性或未受精的卵传递者，并且所有假阴性中52％被发现仅感染雄性。性别比范围为0.74-0.82（男/女）。据测算，农村地区基本生育率在1.16-2.11之间，但部分地区已接近“临界点”。据观察，过去 17 年“U 率”从 19.4%（1973 年）增加到 61.1%（1989 年）。根据对6个农村地区的调查，平均每人口寄生虫负担为2.2只，每名感染者平均寄生虫负担为4.5只。农村社区人均蛔虫频率分布模式很好地符合负二项分布。季节性波动表现为两个较小和较大的峰值。学生群体的年患病率1969年为55.4%，1989年下降到0.3%，可见，下降的主要原因是国家防治工程。事实证明，在长期防治方案中使用四分之一剂量的双羟萘酸噻嘧啶的疗效几乎与常规剂量（10 mg/kg）相当。通过2年的观察评估了各种间隔大规模化疗方案的比较疗效，并证实至少需要每两年进行一次大规模化疗才能逐渐降低再感染。在一个村庄中间隔两个月进行全面治疗的情况下，在初次治疗后的 28 个月内，所有居民都没有再感染。人们充分认识到，如果没有政府支持的具体立法和组织，国家大规模控制计划几乎没有成功的机会，特别是在发展中国家。（摘要截断为400字）
In view of the epidemiology and control strategy, ascariasis was reviewed with special reference to the data obtained for the past years in Korea. The range of length and prepatent period of A. lumbricoides to become fertile were 12.5-13.5 cm and 1.8-2.1 months for females, and 10.5-11.5 cm and 2.1-2.5 months for males, respectively. In the female worm burden 1 per case, the egglaying capacity steadily increased from 12.6 cm of their length up to 25.0 cm and then decreased significantly after their growth to 27.5 cm. Analysed the egg discharging pattern, it was turned out that the cases with six or more worms have no probability to be false negative or unfertilized ova passer, and 52% of all false negatives were found infected only with male(s). The sex ratio was in the range of 0.74-0.82 (male/female). Basic reproductive rate was calculated in the range of 1.16-2.11 in rural areas, but it was approaching nearly to the 'break point' in some areas. It was observed that the 'U-rate' was increased from 19.4% (1973) to 61.1% (1989) for the past seventeen years. According to the survey in 6 rural areas, the average worm burden was 2.2 per population and 4.5 per infected. The frequency distribution pattern of A. lumbricoides per person in a rural community was well fitted to the negative binomial distribution. Seasonal fluctuation was shown in two, smaller and larger, peaks. The annual prevalence in student group was initially 55.4% in 1969, but decreased to 0.3% in 1989, and it is evident that the decrease has been greatly owing to the national control project. It was proved that the efficacy of a quarter dose of pyrantel pamoate used in long term control programme was almost equal to that of conventional dose (10 mg/kg). The comparatie efficacy of various interval mass chemotherapy schemes was evaluated through 2 year observations, and it was confirmed that at least biannual mass chemotherapy is necessitated to expect gradual lowering of reinfection. In the case of blanket treatments with 2-month interval in a village, all of inhabitants have been free from reinfection for the period of 28 months after the initial treatment. It was fully recognized that without specific legislation and organization supported by the government, the national mass control programme has almost no chance of success, especially in developing countries.(ABSTRACT TRUNCATED AT 400 WORDS)