Comparison of Cardiovascular Magnetic Resonance and Single-Photon Emission Computed Tomography in Women With Suspected Coronary Artery Disease From the Clinical Evaluation of Magnetic Resonance Imaging in Coronary Heart Disease (CE-MARC) Trial
Comparison of Cardiovascular Magnetic Resonance and Single-Photon Emission Computed Tomography in Women With Suspected Coronary Artery Disease From the Clinical Evaluation of Magnetic Resonance Imaging in Coronary Heart Disease (CE-MARC) Trial
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DOI：
10.1161/circulationaha.112.000071
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发表时间：
2014-03-11
期刊：
影响因子：
37.8
通讯作者：
Plein, Sven
中科院分区：
文献类型：
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作者：
Greenwood, John P.;Motwani, Manish;Plein, Sven
背景-冠状动脉疾病是女性死亡的主要原因，而漏诊是导致高死亡率的原因。这项研究比较了心血管磁共振(CMR)和单光子发射计算机断层扫描(SPECT)在性别上的诊断性能。方法和结果-共有235名女性和393名男性疑似心绞痛患者接受了CMR、SPECT和X射线血管成像，作为冠心病磁共振成像(CE-MARC)临床评估研究的一部分。CMR包括腺苷负荷/静息灌注、电影成像、晚期Gd增强和磁共振冠状动脉成像。门控性腺苷负荷/静息SPECT采用99m-Tetrofosmin。对于CMR，女性和男性的敏感性相似(88.7%对85.6%；P=0.57)，特异性也相似(83.5%对82.8%；P=0.86)。单光子发射计算机断层扫描的敏感性女性明显低于男性(50.9%对70.8%；P=0.007)，但特异性相似(84.1%对81.3%；P=0.48)。女性组和男性组CMR的敏感性均显著高于SPECT(P
Background-Coronary artery disease is the leading cause of death in women, and underdiagnosis contributes to the high mortality. This study compared the sex-specific diagnostic performance of cardiovascular magnetic resonance (CMR) and single-photon emission computed tomography (SPECT).Methods and Results-A total of 235 women and 393 men with suspected angina underwent CMR, SPECT, and x-ray angiography as part of the Clinical Evaluation of Magnetic Resonance Imaging in Coronary Heart Disease (CE-MARC) study. CMR comprised adenosine stress/rest perfusion, cine imaging, late gadolinium enhancement, and magnetic resonance coronary angiography. Gated adenosine stress/rest SPECT was performed with Tc-99m-tetrofosmin. For CMR, the sensitivity in women and men was similar (88.7% versus 85.6%; P=0.57), as was the specificity (83.5% versus 82.8%; P=0.86). For SPECT, the sensitivity was significantly worse in women than in men (50.9% versus 70.8%; P=0.007), but the specificities were similar (84.1% versus 81.3%; P=0.48). The sensitivity in both the female and male groups was significantly higher with CMR than SPECT (P