THE COLD PRESSOR TEST - EFFECTS ON SYMPATHETIC-NERVE ACTIVITY IN HUMAN-MUSCLE AND SKIN NERVE FASCICLES
THE COLD PRESSOR TEST - EFFECTS ON SYMPATHETIC-NERVE ACTIVITY IN HUMAN-MUSCLE AND SKIN NERVE FASCICLES
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DOI：
10.1111/j.1748-1716.1989.tb08760.x
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发表时间：
1989-11-01
期刊：
影响因子：
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通讯作者：
SUNDLOF, G
中科院分区：
文献类型：
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作者：
FAGIUS, J;KARHUVAARA, S;SUNDLOF, G
在进行冷加压试验期间，即将一只手浸入冰水中（2 . ±. 11名受试者在第二次MSA记录时经历相同的程序。作为一项规则，浸泡引起的MSA的增加，随着再现逐渐减少。的响应显示了广泛的变化之间和受试者内;在同一记录场合的第一次和第二次浸泡之间的个体差异高达七倍，从第一次到第二次记录高达五倍。MSA的增加与冰水的不适程度相关。在9名受试者中，MSA在冰水浸泡时大幅增加，皮内疼痛电刺激的水平等于冰水的不适，但它并不伴随着MSA的任何变化。MSA的增加伴随着血压的增加，并且与血压的增加相关性很好。动脉内血压记录表明，MSA发生在压力水平通常与MSA的总抑制，并在休息时舒张压和MSA之间的线性关系被废除在冰水浸泡。SSA没有表现出与冰水浸泡一致的变化。它的结论是，冷加压试验是一个强大的激活剂的MSA，即压力感受器支配的血管收缩剂流出; MSA有助于血压升高与此操作; MSA操作在另一个血压水平，在操作过程中，压力反射抑制水平因此改变;并且，该反应不是对疼痛的反应。
Micro-electrode multi-unit recordings of muscle nerve sympathetic activity (MSA) involved in cardiovascular homeostasis or skin nerve sympathetic activity (SSA) involved in thermoregulation were made in the right peroneal nerve of 48 healthy volunteers during performance of the cold pressor test, i.e. immersion of one hand in ice water (2 .+-. 0.5.degree.C) for 1 min. Eleven subjects underwent the same procedure on a second MSA recording occasion. As a rule, immersion evoked an increase in MSA, with a gradual decrease on emersion. The response showed a wide range of variation between and within subjects; the intra-individual difference between first and second immersion on the same recording occasion was up to sevenfold, and from first to second recording up to fivefold. The increase in MSA correlated with the degree of discomfort from the ice water. In nine subjects with a large increase in MSA on ice water immersion, intracutaneous painful electrical stimulation to a level equalling the discomfort from the ice water was added, but it was not accompanied by any change in MSA. The increase in MSA was accompained by and correlated quite well with an increase in blood pressure. Intra-arterial blood pressure recordings showed that MSA occurred at pressure levels normally associated with total inhibition of MSA, and that an inverse linear relationship between diastolic blood pressure and MSA at rest was abolished during the ice water immersion. SSA showed no consistent change with ice water immersion. It is concluded that the cold pressor test is a powerful activator of MSA, i.e. baroreceptor-governed vasoconstrictor outflow; that MSA contributes to the blood pressure elevation with this manoeuvre; that MSA operates at another blood pressure level during the manoeuvre and that the baroreflex inhibitory level consequently is changed; and that the response is not a reaction to pain only.