Frequency and topography of cerebral microbleeds in dementia with Lewy bodies compared to Alzheimer's disease
Frequency and topography of cerebral microbleeds in dementia with Lewy bodies compared to Alzheimer's disease
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DOI：
10.1016/j.parkreldis.2015.07.008
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发表时间：
2015-09-01
影响因子：
4.1
通讯作者：
Kantarci, Kejal
中科院分区：
文献类型：
--
作者：
Gungor, Ipek;Sarro, Lidia;Kantarci, Kejal
目的：比较路易体痴呆（DLB）与阿尔茨海默病痴呆（AD）脑微出血（CMBs）的频率和分布。方法：比较连续接受3- tt2 *加权梯度回忆回声MRI检查的疑似DLB患者（n = 23）和年龄、性别匹配的疑似阿尔茨海默病患者（n = 46）发生CMBs的频率和部位。结果：DLB患者（30%）和AD患者（24%）中出现一个或多个CMBs的频率相似。在DLB和AD患者的枕叶中发现了最高密度的CMBs。AD患者在顶叶、颞叶和幕下区域的CMBs密度高于DLB （p < 0.05）。结论：CMBs在DLB患者中与AD患者一样常见，在枕叶中观察到的密度最高，提示两种疾病中CMBs的共同病理生理机制。(C) 2015年作者。Elsevier Ltd.出版。
Aim: To determine the frequency and topographic distribution of cerebral microbleeds (CMBs) in dementia with Lewy bodies (DLB) in comparison to CMBs in Alzheimer disease dementia (AD).Methods: Consecutive probable DLB (n = 23) patients who underwent 3-T T2* weighted gradient-recalled-echo MRI, and age and gender matched probable Alzheimer's disease patients (n = 46) were compared for the frequency and location of CMBs.Results: The frequency atone or more CMBs was similar among patients with DLB (30%) and AD (24%). Highest densities of CMBs were found in the occipital lobes of patients with both DLB and AD. Patients with AD had greater densities of CMBs in the parietal, temporal lobes and infratentorial regions compared to DLB (p < 0.05).Conclusion: CMBs are as common in patients with DLB as in patients with AD, with highest densities observed in the occipital lobes, suggesting common pathophysiologic mechanisms underlying CMBs in both diseases. (C) 2015 The Authors. Published by Elsevier Ltd.