A nosocomial outbreak of Crimean-Congo haemorrhagic fever at Tygerberg Hospital. Part I. Clinical features.
A nosocomial outbreak of Crimean-Congo haemorrhagic fever at Tygerberg Hospital. Part I. Clinical features.
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泰格伯格医院爆发了克里米亚-刚果出血热的院内疫情。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
Groenewald Jh
中科院分区：
文献类型：
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作者：
van Eeden Pj;Joubert;Van de Wal Bw;King Jb;A. DeKock;Groenewald Jh
克里米亚-刚果出血热(CCHF)是南非的一种罕见疾病。从1981年到1984年9月，报告了8例散发性原发病例。本文描述了某大型大学医院发生的一起CCHF暴发，确诊的8例患者中有2例死亡(指数和1例继发病例)。4名患者病情严重，2名患者病情轻微。在诊断这种疾病时遇到了一些问题，这种疾病最初表现为流感样症状，与流感的严重程度只有不同。然而，瘀点和其他出血倾向的表现将它与疾病后期的流感区分开来。特殊检查，特别是那些发现白细胞减少和血小板减少的检查，在早期诊断中至关重要。处理这种高传染性疾病的两难境地是，确定的病毒学诊断是耗时的，而且只在1600公里外的一个高度安全的实验室进行。3个月后，从另一个地方又确诊了一例病例，并经病毒学确诊，但无法确认或追踪到任何继发性病例。
Crimean-Congo haemorrhagic fever (CCHF) is a rare disease in South Africa. From 1981 to September 1984, 8 sporadic primary cases were reported. An outbreak of CCHF in a large university hospital is described; of 8 patients diagnosed 2 died (the index and a secondary case). Four patients were seriously ill and 2 had a mild illness. Problems were encountered in diagnosing the disease, which presents initially with influenza-like symptoms, differing only in severity from influenza. However, petechiae and other manifestations of a bleeding tendency distinguished it from influenza in the later phase of the disease. Special investigations, especially those revealing leucopenia and thrombocytopenia, were critically important in early diagnosis. The dilemma of handling this highly contagious disease is that definite virological diagnosis is time-consuming and is conducted in only one high-security laboratory 1600 km distant. A further case was admitted 3 months later from a different locality and confirmed virologically but no secondary cases could be confirmed or traced.