Positron emission tomography quantification of serotonin-1A receptor binding in medication-free bipolar depression.
Positron emission tomography quantification of serotonin-1A receptor binding in medication-free bipolar depression.
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DOI：
10.1016/j.biopsych.2009.01.028
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发表时间：
2009-08-01
影响因子：
10.6
通讯作者：
Parsey, Ramin V.
中科院分区：
文献类型：
--
作者：
Sullivan, Gregory M.;Ogden, R. Todd;Oquendo, Maria A.;Kumar, J. S. Dileep;Simpson, Norman;Huang, Yung-yu;Mann, J. John;Parsey, Ramin V.
Little is known about the serotonin1A receptor (5-HT1A) in bipolar depression despite altered 5-HT1A binding in major depressive disorder (MDD). Utilizing PET and the radioligand [C-11]WAY100635, regional 5-HT1A binding was compared between depressed bipolar disorder (BD) and control subjects. Brain 5-HT1A binding potential (BPF = Bmax/KD, where Bmax is the total number of available receptors and 1/KD is the receptor affinity of the ligand) was measured in 32 currently depressed, medication-free BD subjects and 47 healthy controls. Participants were also genotyped for the 5-HT1A promoter polymorphism C(-1019)G. The bipolar depressed group demonstrated higher 5-HT1A BPF across all regions of interest (ROIs; p=0.022). Post-hoc analyses indicated that male BD patients had higher 5-HT1A BPF than male controls (p=0.025), with higher 5-HT1A BPF found in every region (by 102% in raphe nuclei and 31-54% in the 12 forebrain ROIs). Whereas, female subgroups did not differ in 5-HT1A BPF (p=0.32). 5-HT1A BPF did not correlate with depression severity. The GG genotype was overrepresented at a trend level in the BD group (p=0.057). Number of copies of the G-allele was associated with higher 5-HT1A BPF in raphe (p=0.0050), amygdala (p=0.022), and hippocampus (p=0.041). Higher 5-HT1A BPF in depressed males with BD suggests higher raphe autoreceptor binding, potentially causing less serotonin release and compensatory upregulation of postsynaptic 5-HT1A receptors in forebrain regions. The raphe effect may be partly genetic. Lack of difference in 5-HT1A BPF between BD and control females may reflect greater effect of prior antidepressant exposure in BD females.
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DOI：
10.1017/s1461145707008140
发表时间：
2008-06-01
影响因子：
4.8
作者：
Hirvonen, Jussi;Karlsson, Hasse;Hietala, Jarmo
通讯作者：
Hietala, Jarmo
影响因子：
5.7
作者：
Jovanovic, Hristina;Lundberg, Johan;Nordstrom, Anna-Lena
通讯作者：
Nordstrom, Anna-Lena
影响因子：
--
作者：
Judd, LL;Akiskal, HS;Keller, MB
通讯作者：
Keller, MB
DOI：
10.1017/s1461145704004663
发表时间：
2004-12-01
影响因子：
4.8
作者：
Huang, YY;Battistuzzi, C;Mann, JJ
通讯作者：
Mann, JJ
影响因子：
3.4
作者：
GELFIN, Y;LERER, B;ALLOLIO, B
通讯作者：
ALLOLIO, B