Large prospective investigation of meat intake, related mutagens, and risk of renal cell carcinoma
Large prospective investigation of meat intake, related mutagens, and risk of renal cell carcinoma
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DOI：
10.3945/ajcn.111.019364
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发表时间：
2012-01-01
影响因子：
7.1
通讯作者：
Sinha, Rashmi
中科院分区：
文献类型：
--
作者：
Daniel, Carrie R.;Cross, Amanda J.;Sinha, Rashmi
背景：肉类摄入量和肾细胞癌（RCC）风险的证据不一致。与肉类烹饪和加工相关的突变，以及RCC亚型的变化可能是重要的考虑。目的：在一个大型的美国队列中，我们前瞻性地研究了肉类和肉类相关化合物的摄入与RCC风险的关系，以及透明细胞和乳头状RCC组织学亚型。设计：研究参与者（492，186）完成了一项详细的饮食评估，该评估与血红素铁，杂环胺（HCA），多环芳烃（PAH），硝酸盐，和加工肉类中的亚硝酸盐浓度。超过9年（平均）的后续行动，我们确定了1814例肾细胞癌（498透明细胞癌和115乳头状腺癌）。使用多变量考克斯比例风险回归，在五分位数内估计HR和95%CI。（五分位数5）与9.8 g相比（五分位数1）每1000千卡（中位数）]与肾细胞癌风险增加的趋势相关[HR：1.19; 95%CI：1.01，1.40; P趋势= 0.06]和乳头状RCC的风险增加2倍[P趋势= 0.002]。苯并（a）芘（BaP）（多环芳烃的标志物）和2-氨基-1-甲基-6-苯基-咪唑并[4，5-B]吡啶（PhIP）（HCA）的摄入与肾癌风险显著升高20-30%和乳头状肾癌风险增加2倍相关。没有协会观察到的透明细胞subtype.Conclusions：红肉摄入量可能会增加肾细胞癌的风险，通过机制有关的烹饪化合物苯并（a）芘和苯并（b）芘。我们对肾细胞癌的发现似乎与罕见的乳头状组织学变异有很强的相关性。本研究在clinicaltrials.gov注册为NCT 00340015。美国临床营养杂志2012;95：155-62。
Background: The evidence for meat intake and renal cell carcinoma (RCC) risk is inconsistent. Mutagens related to meat cooking and processing, and variation by RCC subtype may be important to consider.Objective: In a large US cohort, we prospectively investigated intake of meat and meat-related compounds in relation to risk of RCC, as well as clear cell and papillary RCC histologic subtypes.Design: Study participants (492,186) completed a detailed dietary assessment linked to a database of heme iron, heterocyclic amines (HCA), polycyclic aromatic hydrocarbons (PAHs), nitrate, and nitrite concentrations in cooked and processed meats. Over 9 (mean) y of follow-up, we identified 1814 cases of RCC (498 clear cell and 115 papillary adenocarcinomas). HRs and 95% CIs were estimated within quintiles by using multivariable Cox proportional hazards regression.Results: Red meat intake [62.7 g (quintile 5) compared with 9.8 g (quintile 1) per 1000 kcal (median)] was associated with a tendency toward an increased risk of RCC [HR: 1.19; 95% CI: 1.01, 1.40; P-trend = 0.06] and a 2-fold increased risk of papillary RCC [P-trend = 0.002]. Intakes of benzo(a) pyrene (BaP), a marker of PAHs, and 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP), an HCA, were associated with a significant 20-30% elevated risk of RCC and a 2-fold increased risk of papillary RCC. No associations were observed for the clear cell subtype.Conclusions: Red meat intake may increase the risk of RCC through mechanisms related to the cooking compounds BaP and PhIP. Our findings for RCC appeared to be driven by strong associations with the rarer papillary histologic variant. This study is registered at clinicaltrials.gov as NCT00340015. Am J Clin Nutr 2012;95:155-62.