WHICH FRACTURES ARE ASSOCIATED WITH LOW APPENDICULAR BONE MASS IN ELDERLY WOMEN
WHICH FRACTURES ARE ASSOCIATED WITH LOW APPENDICULAR BONE MASS IN ELDERLY WOMEN
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DOI：
10.7326/0003-4819-115-11-837
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发表时间：
1991-12-01
影响因子：
39.2
通讯作者：
CUMMINGS, SR
中科院分区：
文献类型：
--
作者：
SEELEY, DG;BROWNER, WS;CUMMINGS, SR
目的：目的：确定低外展骨量老年女性中哪种类型的骨折发生率较高。设计：前瞻性队列研究。地点：美国的4个临床中心（巴尔的摩，马里兰州;明尼阿波利斯，明尼苏达州;波特兰，俄勒冈州;莫南盖赫拉谷，宾夕法尼亚州）;和一个协调中心，位于旧金山弗朗西斯科，加州。年龄在65岁或以上的非黑人女性（9704）从基于人群的listings.Measurements中招募：我们使用单光子吸收法测量桡骨远端和近端以及跟骨的骨量。通过X线片验证骨折。协会计算为年龄调整的风险比（95%CI）每标准差降低bone mass.Main结果：在平均随访2.23年，841非脊柱骨折发生在753名妇女。腕、足、肱骨、髋、肋骨、脚趾、小腿、骨盆、手和锁骨骨折的风险与骨量减少显著相关（P < 0.05）。这些骨折占非脊柱骨折的74%。在桡骨远端发生一处或多处骨折的总体风险比为1.65（CI，1.49 - 1.82）。在队列的子样本中，椎骨骨折也与低骨量有关。骨折的踝关节，肘关节，手指，和脸，但是，没有相关的骨量在任何测量网站，这些骨折的总体风险比为1.12（CI，0.96至1.30）在远端radiation.Conclusion：大多数类型的骨折的发生率增加，低骨量的老年妇女。
Objective: To determine which types of fractures have an increased incidence in elderly women with low appendicular bone mass.Design: Prospective cohort study.Setting: Four clinical centers in the United States (Baltimore, Maryland; Minneapolis, Minnesota; Portland, Oregon; Monangehela Valley, Pennsylvania); and one coordinating center in San Francisco, California.Subjects: Ambulatory, nonblack women (9704) aged 65 years or more who were recruited from population-based listings.Measurements: We measured bone mass at the distal and proximal radius and calcaneus using single-photon absorptiometry. Fractures were verified radiographically. Associations were calculated as age-adjusted hazard ratios (with 95% CIs) per standard deviation decrease in bone mass.Main Results: During a mean follow-up of 2.23 years, 841 nonspinal fractures occurred in 753 women. The risks for fractures of the wrist, foot, humerus, hip, rib, toe, leg, pelvis, hand, and clavicle were significantly related to reduced bone mass (P < 0.05). These fractures represented 74% of nonspinal fractures. The overall hazard ratio for the occurrence of one or more of these fractures was 1.65 (CI, 1.49 to 1.82) at the distal radius. In a subsample of the cohort, vertebral fractures were also related to low bone mass. Fractures of the ankle, elbow, finger, and face, however, were not associated with bone mass at any measurement site; the overall hazard ratio for these fractures was 1.12 (CI, 0.96 to 1.30) at the distal radius.Conclusion: Most types of fractures have an increased incidence in elderly women with low bone mass.