FAMILIAL ENDOMETRIOSIS
FAMILIAL ENDOMETRIOSIS
复制标题
DOI：
10.1007/bf02214126
复制
发表时间：
1995-01-01
影响因子：
3.1
通讯作者：
BARLOW, D
中科院分区：
文献类型：
--
作者：
KENNEDY, S;MARDON, H;BARLOW, D
用途：本研究的目的是确定家庭子宫内膜异位症，并记录疾病的严重程度在家庭和临床特点的受影响women.Results：230名妇女手术证实子宫内膜异位症在100个家庭。这些家庭包括19对母女、1对堂兄妹和56对姐妹。有5个家庭有3个患病姐妹篇，1个家庭有5个患病姐妹篇，18个家庭在一代以上有大于或等于3个患病成员。症状发作时的平均年龄和手术诊断时的平均年龄为22.1 ± 8.8 SD（范围10-46）和31.8 +/- 7.9 SD（范围15-56）岁，79名妇女（34.3%）有修订的AFS I-II期疾病，（65.7%）有修订的AFS III-IV期疾病。这项研究证实了子宫内膜异位症的常见倾向，并支持子宫内膜异位症有遗传基础的假设。
Purpose: The study aimed to identify families with endometriosis and to document disease severity within the families and the clinical characteristics of the affected women.Results: Two hundred and thirty women with surgically confirmed endometriosis in 100 families were identified. The families consisted of 19 mother-daughter pairs, 1 set of cousins and 56 sister pairs. There were 5 families with 3 affected sisters, 1 family with 5 affected sisters, and 18 families with greater than or equal to 3 affected members in more than one generation. The mean age at the onset of symptoms and the mean age at surgical diagnosis was 22.1 +/- 8.8 SD (range 10-46) and 31.8 +/- 7.9 SD (range 15-56) years respectively, Seventy-nine women (34.3%) had revised AFS Stage I-II disease, and 151 (65.7%) had revised AFS Stage III-IV disease.Conclusion: The study confirms a familiar tendency for endometriosis and supports the hypothesis that endometriosis has a genetic basis.