Enhanced nociception by exogenous and endogenous substance P given into the spinal cord in mice lacking NR2A/ε1, an NMDA receptor subunit
Enhanced nociception by exogenous and endogenous substance P given into the spinal cord in mice lacking NR2A/ε1, an NMDA receptor subunit
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DOI：
10.1038/sj.bjp.0703056
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发表时间：
2000-01
影响因子：
7.3
通讯作者：
M. Inoue;M. Mishina;H. Ueda
中科院分区：
文献类型：
--
作者：
M. Inoue;M. Mishina;H. Ueda
In capsaicin‐pretreated mice, the nociceptive responses induced by intrathecally (i.t.) administered substance P (SP) were enhanced by N‐methyl‐D‐aspartate (NMDA)‐type receptor antagonists, dizocilpine (MK801) and D‐2‐amino‐5‐phosphonopentanoate (D‐AP5) in a dose‐dependent manner. Similar enhancement of SP‐induced nociception was also observed in mice lacking the NMDA‐type glutamate receptor NR2A/ε1subunit gene (GluRε1−/−mice). On the other hand, GluRε1−/−mice showed a marked enhancement of the peripheral nociceptive responses induced by intraplantar (i.pl.) injection of SP and bradykinin (BK). As the nociceptive responses to SP and BK (i.pl.) were both antagonized by CP‐99994, an neurokinin1(NK1) antagonist (i.t.), these results suggest that GluRε1receptor may play an inhibitory role in the downstream mechanisms of primary nociceptive SP neurones, possibly through activation of unidentified inhibitory neurones.British Journal of Pharmacology(2000)129, 239–241; doi:10.1038/sj.bjp.0703056
