Dissipative metabolic patterns respond during neutrophil transmembrane signaling.
Dissipative metabolic patterns respond during neutrophil transmembrane signaling.
复制标题
耗散代谢模式在中性粒细胞跨膜信号传导过程中做出反应。
DOI：
10.1073/pnas.061014298
复制
发表时间：
2001
影响因子：
11.1
通讯作者：
Kindzelskii,AL
中科院分区：
文献类型：
--
作者：
Petty,HR;Kindzelskii,AL
自组织是生物学中的一个共同主题。自组织的一种机制是通过化学反应物的扩散和它们的非线性相互作用产生化学图案。我们最近观察到持续单向行进化学氧化还原[NAD（P）H − NAD（P）+]波在活的极化中性粒细胞。目前的研究表明，细胞内代谢波响应甲酰肽受体激动剂，但不是拮抗剂，分裂成两个波在相反的方向沿着细胞的长轴。在其他嗜中性粒细胞活化物质中也观察到类似的效果。此外，当细胞暴露于一个N-甲酰基-甲硫氨酰-亮氨酰-苯丙氨酸（FMLP）的梯度，其来源是垂直于细胞的长轴，细胞代谢局部扰动的图案在垂直于初始细胞轴的方向上的重新取向。 因此，细胞外激活信号和信号的空间线索被翻译成不同的细胞内耗散结构。
Self-organization is a common theme in biology. One mechanism of self-organization is the creation of chemical patterns by the diffusion of chemical reactants and their nonlinear interactions. We have recently observed sustained unidirectional traveling chemical redox [NAD(P)H − NAD(P)+] waves within living polarized neutrophils. The present study shows that an intracellular metabolic wave responds to formyl peptide receptor agonists, but not antagonists, by splitting into two waves traveling in opposite directions along a cell's long axis. Similar effects were noted with other neutrophil-activating substances. Moreover, when cells were exposed to anN-formyl-methionyl-leucyl-phenylalanine (FMLP) gradient whose source was perpendicular to the cell's long axis, cell metabolism was locally perturbed with reorientation of the pattern in a direction perpendicular to the initial cellular axis. Thus, extracellular activating signals and the signals' spatial cues are translated into distinct intracellular dissipative structures.