Retrolental Fibroplasia. II. Pathologic correlation.
Retrolental Fibroplasia. II. Pathologic correlation.
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晶状体后纤维增生。
DOI：
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
J. Flynn
中科院分区：
文献类型：
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作者：
B. Kushner;D. Essner;I. Cohen;J. Flynn
通过肉眼观察并使用 PAS 染色整体、胰蛋白酶消化和常规组织学技术，研究了 71 名已进行尸检的早产儿的 142 只眼睛的视网膜。通过这些技术，在患有急性晶状体后纤维增生的活婴儿中，血管病理状况与荧光素血管造影相关。急性期所见的具体病变是眼睛中的主要动静脉分流、微血管变化，包括簇状形成以及动脉和静脉周围毛细血管的闭塞。通过分流器前缘的血管出芽而发生消退。对正常血管形成的观察表明，视网膜脉管系统的成熟水平存在差异，仅与胎龄大致相关。
Retinas of 142 eyes from 71 premature infants on whom autopsies had been done were studied by gross observation and by using PAS-stained whole mount, trypsin-digest, and conventional histological techniques. With these techniques, vascular pathologic condition was correlated with fluorescein angiograms in living infants with acute retrolental fibroplasia. The specific lesions seen in acute phase were a major arteriovenous shunt in the eye, microvascular changes including tufting, and obliteration of capillaries around arteries and veins. Regression occurred by vascular budding from the anterior edge of the shunt. Observations on vascularization in the normal indicated a variability of the level of maturation of the retinal vasculature, only roughly correlated with gestational age.