Molecular Detection and Phylogenetic Characteristics of Herpesviruses in Rectal Swab Samples from Rodents and Shrews in Southern China
Molecular Detection and Phylogenetic Characteristics of Herpesviruses in Rectal Swab Samples from Rodents and Shrews in Southern China
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华南地区啮齿动物和鼩鼱直肠拭子样本中疱疹病毒的分子检测及系统发育特征
DOI：
10.1089/vbz.2015.1908
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发表时间：
2016-07-01
影响因子：
2.1
通讯作者：
Chen, Qing
中科院分区：
文献类型：
--
作者：
Zheng, Xue-yan;Qiu, Min;Chen, Qing
疱疹病毒 (HV) 可在多种动物中引起无症状、良性或致命感染。然而，人们对中国啮齿类和鼩鼱中HV的流行情况和系统发育特征知之甚少。因此，我们于2012年至2014年间对中国南方地区的大鼠和鼩鼱的HV进行了分子检测和系统发育分析。255份大鼠直肠拭子标本中的17份（6.7%）和90份鼩鼱直肠拭子标本中的6份（6.7%）检测出HV阳性。系统发育分析表明，本研究中检测到的啮齿动物和鼩鼱 HV 具有物种特异性，聚集在 Betaherpesvirinae 和 Gammaherpesvirinae 进化枝中。在褐家鼠 (RN/13YX52/24 和 RN/14HC50) 中检测到新型马卡病毒，在鼠鼯 (SM/14BY7/16/20/97/99/106) 中检测到伽马疱疹病毒。这些发现有助于我们了解 HV 的分类学、系统发育和生物学。
Herpesviruses (HVs) can cause asymptomatic, benign, or fatal infections in a variety of animal species. However, the prevalence and phylogenetic characteristics of HVs in rodents and shrews in China are poorly understood. We thus performed a molecular detection and phylogenetic analysis of rat and shrew HVs in southern China between 2012 and 2014. Seventeen (6.7%) of 255 rectal swab specimens from rats and six (6.7%) of 90 rectal swab specimens from shrews tested positive for HVs. Phylogenetic analysis revealed that rodent and shrew HVs detected in this study were species specific, clustering in the Betaherpesvirinae and Gammaherpesvirinae clade. Novel Macavirus was detected in Rattus norvegicus (RN/13YX52/24 and RN/14HC50) and gammaherpesviruses in Suncus murinus (SM/14BY7/16/20/97/99/106). These findings have contributed to our understanding of the taxonomy, phylogeny, and biology of HVs.