Dynamics of platelet thrombus formation
Dynamics of platelet thrombus formation
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DOI：
10.1111/j.1538-7836.2009.03401.x
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发表时间：
2009-07-01
影响因子：
10.4
通讯作者：
Westein, E.
中科院分区：
文献类型：
--
作者：
Jackson, S. P.;Nesbitt, W. S.;Westein, E.
动脉粥样硬化斑块破裂部位的血小板聚集和血栓形成是一个动态过程，可导致间歇性或永久性血流阻塞，导致缺血性组织损伤和器官功能障碍。越来越多的证据表明，血小板聚集和初始血栓形成的动力学受到两个不同的、互补的过程的调节，包括：(i) 流变学（生物力学）和 (ii) 可溶性激动剂依赖性机制。流变依赖性血小板聚集发生在盘状血小板之间，需要主要血小板粘附受体 GPIb 和整合素 α(IIb)β(3) 的生物力学粘附和信号功能（机械转导）。可溶性激动剂进一步增强血小板活化，刺激整体血小板形状变化和脱粒，并在稳定形成的聚集体中发挥重要作用。揭示体内血小板聚集和血栓形成的动力学需要考虑流变学和可溶性激动剂依赖性血小板聚集机制之间的协同相互作用。
Platelet aggregation and thrombus formation at sites of atherosclerotic plaque rupture is a dynamic process that can lead to intermittent or permanent obstruction to blood flow, resulting in ischemic tissue injury and organ dysfunction. There is a growing body of evidence suggesting that the dynamics of platelet aggregation and initial thrombus development are regulated by two distinct, complementary processes, involving: (i) rheological (biomechanical) and (ii) soluble-agonist-dependent mechanisms. Rheological-dependent platelet aggregation occurs between discoid platelets and requires the biomechanical adhesive and signaling function (mechanotransduction) of the major platelet adhesion receptors, GPIb and integrin alpha(IIb)beta(3). Soluble agonists further potentiate platelet activation, stimulating global platelet shape change and degranulation, and play a major role in stabilizing formed aggregates. Unraveling the dynamics of platelet aggregation and thrombus formation in vivo requires consideration of the cooperative interplay between rheological- and soluble agonist-dependent platelet aggregation mechanisms.