The Behavioral Relevance of Task Information in Human Prefrontal Cortex
The Behavioral Relevance of Task Information in Human Prefrontal Cortex
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DOI：
10.1093/cercor/bhv072
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发表时间：
2016-06-01
期刊：
影响因子：
3.7
通讯作者：
Braver, Todd S.
中科院分区：
文献类型：
--
作者：
Cole, Michael W.;Ito, Takuya;Braver, Todd S.
人类外侧前额叶皮层（LPFC）被认为在实现认知灵活性方面起着关键作用，特别是在执行新任务时。然而，它仍然有待确定是否LPFC代表任务相关的信息，在这种情况下，实际上有助于成功的业绩。我们利用功能性MRI活动的模式分类分析来识别新奇敏感的大脑区域，因为参与者在64项复杂任务的执行之间快速切换，其中60项是新颖的。在三个这些新奇的敏感区域位于不同地区的左前LPFC试验诱发的活动模式区分正确的错误试验。此外，这些区域还包含有关任务相关决策规则的信息，但仅适用于成功进行的试验。这表明，左前LPFC可能是特别重要的代表任务信息，有助于认知灵活性需要成功地执行新的任务情况。
Human lateral prefrontal cortex (LPFC) is thought to play a critical role in enabling cognitive flexibility, particularly when performing novel tasks. However, it remains to be established whether LPFC representation of task-relevant information in such situations actually contributes to successful performance. We utilized pattern classification analyses of functional MRI activity to identify novelty-sensitive brain regions as participants rapidly switched between performance of 64 complex tasks, 60 of which were novel. In three of these novelty-sensitive regions-located within distinct areas of left anterior LPFC-trial-evoked activity patterns discriminated correct from error trials. Further, these regions also contained information regarding the task-relevant decision rule, but only for successfully performed trials. This suggests that left anterior LPFC may be particularly important for representing task information that contributes to the cognitive flexibility needed to perform successfully in novel task situations.