Cold-insoluble globulin mediates the adhesion of rat liver cells to plastic Petri dishes.
Cold-insoluble globulin mediates the adhesion of rat liver cells to plastic Petri dishes.
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冷不溶性球蛋白介导大鼠肝细胞与塑料培养皿的粘附。
DOI：
10.1016/0006-291x(77)91172-x
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发表时间：
1977
影响因子：
3.1
通讯作者：
A. Vaheri
中科院分区：
文献类型：
--
作者：
M. Höök;K. Rubin;A. Oldberg;B. Obrink;A. Vaheri
大鼠肝细胞与塑料培养皿的黏附需要一个存在于正常血浆或血清中的因子，该因子暂时被鉴定为冷不溶球蛋白，因为(I)冷不溶球蛋白是唯一被测试的具有细胞黏附调节活性的天然血浆蛋白，以及(Ii)选择性地去除冷不溶球蛋白的血浆失去了诱导细胞黏附的能力。在某些情况下，去甲蓝蛋白也成为一种有效的细胞黏附介导剂。然而，分别由去唾液酸角蛋白和冷不溶性球蛋白介导的细胞附着被证明涉及不同的机制。
Adhesion of rat hepatocytes to plastic culture dishes requires a factor present in normal plasma or serum which tentatively is identified as cold-insoluble globulin since(i)cold-insoluble globulin was the only native plasma protein tested showing cell-adhesion mediating activity, and(ii)plasma from which cold-insoluble globulin selectively had been removed lost its ability to induce cell attachment.Under certain circumstances also asialoceruloplasmin became a potent cell adhesion mediating agent. However, cell attachment mediated by asialoceruloplasmin and cold-insoluble globulin, respectively, was demonstrated to involve separate mechanisms.