Alteration of mitochondrial structure and heme biosynthetic parameters in liver and kidney cells by bismuth.
Alteration of mitochondrial structure and heme biosynthetic parameters in liver and kidney cells by bismuth.
复制标题
铋改变肝和肾细胞中线粒体结构和血红素生物合成参数。
DOI：
10.1016/0041-008x(87)90335-8
复制
发表时间：
1987
影响因子：
3.8
通讯作者：
Fowler,BA
中科院分区：
文献类型：
--
作者：
Woods,JS;Fowler,BA
Ultrastructural and biochemical studies were conducted to evaluate the effects of bismuth, a potentially toxic group V trace metal, on organelle structure and heme biosynthetic parameters in rat liver and kidney cells. Bismuth subnitrate (BiONO3) was administered subcutaneously to male rats in 0, 20, 40, or 80 mg/kg doses 16 hr prior to euthanasia. Electron microscopy revealed swollen mitochondria and distortion of mitochondrial inner membranes in liver and renal proximal tubule cells at 40 and 80 mg/kg dose levels. In liver, dose-related decreases were observed in the activities of the mitochondrial enzymes, δ-aminolevulinic acid (ALA) synthetase and heme synthetase, and of the cytoplasmic enzyme, ALA dehydratase, to 51, 48, and 35% of levels seen in untreated controls, respectively. In kidney, ALA synthetase and ALA dehydratase, but not heme synthetase, were depressed in vivo to 32 and 20% of control, respectively. Studies in vitro conducted for 1-hr periods with Bi concentrations at 0, 0.1, 0.2, or 0.4 mm in reaction mixtures revealed that the direct action of the metal on membranal enzymes only partially accounts for the impairment of the activity of membranal enzymes. These studies demonstrate that the initial acute effects of bismuth in liver and kidney cells include distortion of mitochondrial membranes and direct inhibition of specific heme pathway enzymes. Both effects contribute to compromise of membrane-associated enzymatic functions. These findings are comparable to those previously reported of other trace metals with known toxicologic potential and may represent early events in bismuth-induced cell injury.
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内源性血红蛋白较多制剂中亚铁螯合酶活性的快速分光光度测定及其在大豆根瘤制剂中的应用。
影响因子：
2.9
作者：
R. J. Porra
通讯作者：
R. J. Porra
氯化铊改变肝细胞结构和功能：超微结构、形态测量和生化研究。
影响因子：
3.8
作者：
J. S. Woods;B. Fowler
通讯作者：
B. Fowler
影响因子：
3.6
作者：
FOWLER, BA;WOODS, JS
通讯作者：
WOODS, JS
影响因子：
3.2
作者：
FOWLER, BA;GOYER, RA
通讯作者：
GOYER, RA
造血小鼠脾提取物催化胆色素原向尿卟啉原的酶转化。
DOI：
10.1016/s0021-9258(18)95803-5
发表时间：
1967
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
E. Y. Levin;D. Coleman
通讯作者：
D. Coleman