Nesprins LINC the nucleus and cytoskeleton
Nesprins LINC the nucleus and cytoskeleton
复制标题
DOI：
10.1016/j.ceb.2010.11.006
复制
发表时间：
2011-02-01
影响因子：
7.5
通讯作者：
Shanahan, Catherine M.
中科院分区：
文献类型：
--
作者：
Mellad, Jason A.;Warren, Derek T.;Shanahan, Catherine M.
与其他血影蛋白重复序列蛋白一样，nesprins通过将膜细胞器连接到细胞骨架来协调和维持细胞结构。然而，核膜（NE）nesprins，独特的硬连线核板层的细胞骨架和分子马达。新出现的证据表明，nesprins也形成了一个连续的网络连接质膜NE，可能翻译成核重组的机械刺激。令人惊讶的是，这个网络也是必不可少的细胞骨架组织和它的破坏有显着影响核迁移，中心体定位，粘着斑成熟和细胞运动。在此，我们回顾了最近的进展，我们的理解如何nesprins耦合到细胞内的各种丝状系统，并强调KASH和KASH-少nesprin亚型在这些相互作用的重要性。
Like other spectrin repeat proteins, nesprins co-ordinate and maintain cellular architecture by linking membranous organelles to the cytoskeleton. However nuclear envelope (NE) nesprins, uniquely hardwire the nuclear lamina to the cytoskeleton and molecular motors. Emerging evidence suggests that nesprins also form a continuous network linking the plasma membrane to the NE that potentially translates mechanical stimuli into nuclear reorganisation. Surprisingly, this network is also essential for cytoskeletal organisation and its disruption has dramatic effects on nuclear migration, centrosomal positioning, focal adhesion maturation and cell motility. Herein we review recent advances in our understanding of how nesprins couple to various filamentous systems within the cell and emphasise the importance of both KASH and KASH-less nesprin isoforms in these interactions.