miRNA in pluripotent stem cells.
miRNA in pluripotent stem cells.
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DOI：
10.2217/rme.10.34
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发表时间：
2010-07
影响因子：
2.7
通讯作者：
Hart RP
中科院分区：
文献类型：
--
作者：
Lakshmipathy U;Davila J;Hart RP
Embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC) are characterized by their ability to self renew and differentiate into any cell type. The molecular mechanism behind this process is a complex interplay between the transcriptional factors with epigenetic regulators and signaling pathways. MicroRNAs are an integral part of this regulatory network with essential roles in pluripotent maintenance, proliferation and differentiation. MicroRNAs are a class of small non-coding RNAs that target protein-encoding mRNA to inhibit translation and protein synthesis. Discovered close to two decades ago, microRNAs have rapidly emerged as key regulatory molecules in several critical cellular processes across species. Recent studies have begun to clarify the specific role of microRNA in regulatory circuitries that control self renewal and pluripotency of both ESC and iPSC. These advances suggest a critical role for microRNAs in the process of reprogramming of somatic cells to pluripotent cells.
