Post-Translational Modifications of the TAK1-TAB Complex.
Post-Translational Modifications of the TAK1-TAB Complex.
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DOI：
10.3390/ijms18010205
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发表时间：
2017-01-19
影响因子：
5.6
通讯作者：
Matsuzawa A
中科院分区：
文献类型：
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作者：
Hirata Y;Takahashi M;Morishita T;Noguchi T;Matsuzawa A
转化生长因子-β（TGF-β）激活激酶1（TAK 1）是丝裂原激活蛋白激酶（MAPKKK）家族的成员，其被生长因子和细胞因子如TGF-β、IL-1β和TNF-α激活，并通过激活核因子-κB（NF-κB）和丝裂原激活蛋白（MAP）激酶信号通路介导广泛的生物学过程。已经确定TAK 1的激活状态通过与其结合伴侣TAK 1结合蛋白（TAB 1、TAB 2和TAB 3）形成复合物而受到严格调控。有趣的是，最近的证据表明TAK 1和TAB的翻译后修饰（PTM）在调节TAK 1激活中的重要性。迄今为止，已经发现了TAK 1和TAB的一些PTM，并且这些PTM似乎根据细胞环境微调和协调TAK 1活性。因此，本次审查的重点是最近的进展，在理解的PTMs的TAK 1-TAB复合物。
Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is a member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family that is activated by growth factors and cytokines such as TGF-β, IL-1β, and TNF-α, and mediates a wide range of biological processes through activation of the nuclear factor-κB (NF-κB) and the mitogen-activated protein (MAP) kinase signaling pathways. It is well established that activation status of TAK1 is tightly regulated by forming a complex with its binding partners, TAK1-binding proteins (TAB1, TAB2, and TAB3). Interestingly, recent evidence indicates the importance of post-translational modifications (PTMs) of TAK1 and TABs in the regulation of TAK1 activation. To date, a number of PTMs of TAK1 and TABs have been revealed, and these PTMs appear to fine-tune and coordinate TAK1 activities depending on the cellular context. This review therefore focuses on recent advances in the understanding of the PTMs of the TAK1-TAB complex.