Association between alcohol intake and domain-specific cognitive function in older women
Association between alcohol intake and domain-specific cognitive function in older women
复制标题
DOI：
10.1159/000093532
复制
发表时间：
2006-01-01
影响因子：
5.7
通讯作者：
Messina, Catherine R.
中科院分区：
文献类型：
--
作者：
Espeland, Mark A.;Coker, Laura H.;Messina, Catherine R.
适度饮酒可能与更好的认知功能有关；然而，这种关系可能在认知领域之间有所不同。65-80岁的女性，参加妇女健康倡议（WHI）激素治疗的随机临床试验，通过辅助的WHI记忆研究（平均随访时间为4.5年）和WHI认知衰老研究（平均随访时间为1.7年）进行全球认知功能的年度标准化测试。与不饮酒者相比，适度饮酒（每天53杯）的女性在全球认知功能测试中表现更好。在口头知识、口头流畅性、图形记忆、口头记忆、注意力和工作记忆以及运动速度的测试中，报告有任何酒精摄入的女性也表现得更好（均p < 0.05），但在空间能力方面表现不佳（p = 0.36）。协变量调整后，与从不饮酒者相比，每天饮酒1次的女性在言语知识和音位流畅性方面的平均得分分别高出5.7% （p < 0.001）和5.7% （p = 0.004）。适度的酒精摄入量与更好的认知有关，这可能在与言语知识和音位流畅性相关的功能中表现得最强烈。然而，我们的观察性研究不能排除与未测量因素的混杂关联。版权所有(c) 2006 S. Karger AG，巴塞尔
Moderate levels of alcohol intake may be associated with better cognitive function; however, this relationship may vary between cognitive domains. Women, aged 65-80 years, enrolled in the Women's Health Initiative (WHI) randomized clinical trials of hormone therapy, underwent annual standardized testing for global cognitive function through the ancillary WHI Memory Study (average follow-up of 4.5 years) and domain-specific cognitive function through the WHI Study of Cognitive Aging (average follow-up of 1.7 years). Compared to nondrinkers, women reporting moderate levels of alcohol intake (:53 drinks per day) performed better on a measure of global cognitive function. Women reporting any alcohol intake also performed better on tests of verbal knowledge, verbal fluency, figural memory, verbal memory, attention and working memory, and motor speed (all p < 0.05), but not spatial ability (p = 0.36). After covariate adjustment, mean scores were higher among women reporting >= 1 drink/day by 5.7% for verbal knowledge (p < 0.001) and by 5.7% for phonemic fluency (p = 0.004), compared to never-drinkers. Moderate levels of alcohol intake are associated with somewhat better cognition, which may be expressed most strongly in functions related to verbal knowledge and phonemic fluency. However, our observational study cannot rule out confounding associations with unmeasured factors. Copyright (c) 2006 S. Karger AG, Basel