A feasibility trial of gamma sensory flicker for patients with prodromal Alzheimer's disease.
A feasibility trial of gamma sensory flicker for patients with prodromal Alzheimer's disease.
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DOI：
10.1002/trc2.12178
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Singer AC
中科院分区：
文献类型：
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作者：
He Q;Colon-Motas KM;Pybus AF;Piendel L;Seppa JK;Walker ML;Manzanares CM;Qiu D;Miocinovic S;Wood LB;Levey AI;Lah JJ;Singer AC
我们和合作者发现，伽马频率（40赫兹）的闪烁灯光和声音可以减少阿尔茨海默病（AD）的病理，并改变小鼠的免疫细胞和信号。为了确定这种干预在人类中的可行性，我们测试了延长视听伽马闪烁刺激的安全性、耐受性和每日依从性。10例因潜在AD引起的轻度认知障碍患者在家中接受了4或8周的延迟启动设计，每天1小时的伽玛闪烁视听刺激。伽马闪烁是安全的、可容忍的和可粘附的。参与者的神经活动受到刺激。磁共振成像和脑脊液蛋白质组学显示了初步证据，表明长时间的闪烁影响神经系统中的神经网络和免疫因子。这些发现表明，长时间的伽玛感觉闪烁是安全的、可耐受的、可行的，具有免疫和网络效应的初步迹象，支持进一步研究伽玛刺激在AD中的作用。
We and collaborators discovered that flickering lights and sound at gamma frequency (40 Hz) reduce Alzheimer's disease (AD) pathology and alter immune cells and signaling in mice. To determine the feasibility of this intervention in humans we tested the safety, tolerability, and daily adherence to extended audiovisual gamma flicker stimulation. Ten patients with mild cognitive impairment due to underlying AD received 1‐hour daily gamma flicker using audiovisual stimulation for 4 or 8 weeks at home with a delayed start design. Gamma flicker was safe, tolerable, and adherable. Participants’ neural activity entrained to stimulation. Magnetic resonance imaging and cerebral spinal fluid proteomics show preliminary evidence that prolonged flicker affects neural networks and immune factors in the nervous system. These findings show that prolonged gamma sensory flicker is safe, tolerable, and feasible with preliminary indications of immune and network effects, supporting further study of gamma stimulation in AD.