Enhancing measured diffusion anisotropy in gray matter by eliminating CSF contamination with FLAIR
Enhancing measured diffusion anisotropy in gray matter by eliminating CSF contamination with FLAIR
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DOI：
10.1002/mrm.10703
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发表时间：
2004-02-01
影响因子：
3.3
通讯作者：
Hu, XP
中科院分区：
文献类型：
--
作者：
Ma, XY;Kadah, YM;Hu, XP
在这项工作中，研究了流体衰减反转恢复（FLAIR）对灰质中测量的扩散各向异性的影响。 DTI 数据是在六名正常志愿者使用和不使用 FLAIR 的情况下获得的。实验证明，FLAIR 的应用可导致灰质区域分数各向异性 (FA) 持续增加，这归因于 CSF 部分体积效应的抑制。除了这些实验结果之外，还进行了蒙特卡罗模拟，以确定在本研究的实验条件下噪声对测量的 FA 的影响。实验观察到的噪声影响得到了模拟的证实，表明测量到的 FA 的增加并不是由于与噪声相关的偏差，而是由于扩散各向异性的实际增加。这种增强的扩散各向异性测量可潜在地用于区分灰质中的方向相关结构和跟踪纤维。 (C) 2004 Wiley-Liss, Inc.
In this work, the effect of fluid-attenuated inversion recovery (FLAIR) on measured diffusion anisotropy was investigated in gray matter. DTI data were obtained with and without FLAIR in six normal volunteers. The application of FLAIR was experimentally demonstrated to lead to a consistent increase in fractional anisotropy (FA) in gray-matter regions, which was attributed to suppressed partial volume effects from CSF. In addition to these experimental results, Monte Carlo simulations were performed to ascertain the effect of noise on the measured FA under the experimental conditions of this study. The experimentally observed effect of noise was corroborated by the simulation, indicating that the increase in the measured FA was not due to a noise-related bias but to an actual increase in diffusion anisotropy. This enhanced measurement of diffusion anisotropy can be potentially used to differentiate directionally dependent structure and tracking fibers in gray matter. (C) 2004 Wiley-Liss, Inc.