Quantitative Analysis of a Urine-Based Assay for Detection of Lipoarabinomannan in Patients with Tuberculosis
Quantitative Analysis of a Urine-Based Assay for Detection of Lipoarabinomannan in Patients with Tuberculosis
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DOI：
10.1128/jcm.00363-10
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发表时间：
2010-08-01
影响因子：
9.4
通讯作者：
Dorman, Susan E.
中科院分区：
文献类型：
--
作者：
Shah, Maunank;Martinson, Neil A.;Dorman, Susan E.
尿阿拉伯糖甘露聚糖（LAM）检测是一种很有前途的快速诊断活动性结核病（TB）的方法。在微生物学确诊的TB患者中，定量LAM检测结果随着细菌负荷和免疫抑制而逐渐增加。患有播散性TB和/或晚期HIV的患者是尿液LAM检测可能特别有用的目标人群。
Urinary lipoarabinomannan (LAM) detection is a promising approach for rapid diagnosis of active tuberculosis (TB). In microbiologically confirmed TB patients, quantitative LAM detection results increased progressively with bacillary burden and immunosuppression. Patients with disseminated TB and/or advanced HIV are target populations for whom urine LAM detection may be particularly useful.