A polymeric domain that promotes cellular internalization
A polymeric domain that promotes cellular internalization
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DOI：
10.1021/ja8001716
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发表时间：
2008-04-30
影响因子：
15
通讯作者：
Kiessling, Laura L.
中科院分区：
文献类型：
--
作者：
Kolonko, Erin M.;Kiessling, Laura L.
聚合物已成为强大的生物工具；然而，它们进入细胞内环境的能力是有限的。为了扩展聚合物支架的生物效用，我们使用开环复分解聚合（ROMP）合成了内化结构域。用n胍基团功能化的聚合物可有效地被细胞内化并定位于囊泡和细胞质中。因为这样的合成。由于材料是模块化的，我们预计这种类型的化合物可以通过封端衍生化或嵌段共聚物合成来促进货物的输送。
Polymers have emerged as powerful biological tools; however, their ability to gain access to the intracellular environment is limited. To expand the biological utility of polymer scaffolds, we have synthesized an internalization domain using the ring-opening metathesis polymerization (ROMP). A polymer functionalized with n guanidinium groups is effectively internalized by cells and localized in both vesicles and the cytoplasm. Because the synthesis of such. materials is modular, we anticipate that compounds of this type can be fashioned that facilitate the delivery of cargo via end-cap derivatization or block copolymer synthesis.