A Tetranuclear-Zinc-Cluster-Catalyzed Practical and Versatile Deprotection of Acetates and Benzoates
A Tetranuclear-Zinc-Cluster-Catalyzed Practical and Versatile Deprotection of Acetates and Benzoates
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DOI：
10.1002/chem.201000960
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发表时间：
2010-01-01
影响因子：
4.3
通讯作者：
Mashima, Kazushi
中科院分区：
文献类型：
--
作者：
Iwasaki, Takanori;Agura, Kazushi;Mashima, Kazushi
开发了一种通过与甲醇进行酯交换反应的乙酸酯和苯甲酸酯的新型催化脱酰反应（参见方案）。在催化量的四核锌簇存在下，与各种酸和亲核试剂敏感的官能团的反应有效地进行。该催化适用于反应性较低的乙酸叔酯，其脱酰反应难以通过其他催化剂的酯交换反应实现。
A new catalytic deacylation of acetates and benzoates through transesterification with methanol was developed (see scheme). Reactions with various acid-and nucleophile-sensitive functional groups proceeded efficiently in the presence of a catalytic amount of the tetranuclear zinc cluster. The present catalysis is applicable to less-reactive tertiary acetates, the deacylation of which is difficult to achieve by transesterification with other catalysts.