Serum free light-chain measurements for identifying and monitoring patients with nonsecretory multiple myeloma
Serum free light-chain measurements for identifying and monitoring patients with nonsecretory multiple myeloma
复制标题
DOI：
10.1182/blood.v97.9.2900
复制
发表时间：
2001-05-01
期刊：
影响因子：
20.3
通讯作者：
Bradwell, AR
中科院分区：
文献类型：
--
作者：
Drayson, M;Tang, LX;Bradwell, AR
使用灵敏的自动化免疫测定，在28例非分泌型多发性骨髓瘤患者中的19例血清中检测到κ或λ游离轻链浓度增加（和异常κ/λ比值），另外4例患者的一条或两条轻链受到抑制，其余5例血清的游离右链浓度正常或升高，κ/λ比值基本正常。在随访期间研究的6例单个游离轻链升高的患者中，疾病活动性发生了变化，这反映在游离轻链浓度的变化上。结论是，血清中游离轻链的定量应证明可用于诊断和监测许多非分泌性骨髓瘤患者，（Blood，2001;97：2900-2902）（C）2001，美国血液学会。
Using sensitive, automated immunoassays, increased concentrations of either kappa or lambda flee light chains (and abnormal kappa/lambda ratios) were detected in the sera of 19 of 28 patients with nonsecretory multiple myeloma, Four other patients had suppression of one or both light chains, and the remaining 5 sera had normal or raised free right-chain concentrations with substantially normal kappa/lambda ratios. Six of the patients with an elevated single free light chain, who were studied during follow-up, had changes in disease activity that were reflected by the changes in free light-chain concentrations. It is concluded that quantification of free light chains in serum should prove useful for the diagnosis and monitoring of many patients with nonsecretory myeloma, (Blood, 2001;97: 2900-2902) (C) 2001 by The American Society of Hematology.