GROWTH-HORMONE RESPONSES TO INTRAVENOUS CLONIDINE CHALLENGE CORRELATE WITH BEHAVIORAL IRRITABILITY IN PSYCHIATRIC-PATIENTS AND HEALTHY-VOLUNTEERS
GROWTH-HORMONE RESPONSES TO INTRAVENOUS CLONIDINE CHALLENGE CORRELATE WITH BEHAVIORAL IRRITABILITY IN PSYCHIATRIC-PATIENTS AND HEALTHY-VOLUNTEERS
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DOI：
10.1016/0165-1781(91)90082-z
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发表时间：
1991-11-01
影响因子：
11.3
通讯作者：
SIEVER, LJ
中科院分区：
文献类型：
--
作者：
COCCARO, EF;LAWRENCE, T;SIEVER, LJ
为探讨中枢去甲肾上腺素能受体反应性与冲动性攻击指数之间的关系，在健康男性志愿者和患有严重情感或人格障碍的男性患者中检查了α-2-肾上腺素能受体激动剂可乐定（GH[CLON]）输注后生长激素的反应和Buss-Durkee敌意量表（BDHI）的反应。GH[克隆]值被发现与BDHI“易怒”子量表在所有科目，但特别是在健康志愿者和人格障碍患者显着相关。GH[克隆]值与BDHI“攻击”分量表无关。这些结果表明，在人类中，中枢α-2-肾上腺素能受体反应性在以行为易怒为特征的人格特质中发挥作用，但不是明显的攻击性。
To explore the relationship between central noradrenergic receptor responsivity and indices of impulsive aggression, growth hormone responses to infusions with the alpha-2-adrenergic receptor agonist clonidine (GH[CLON]) and responses on the Buss-Durkee Hostility Inventory (BDHI) were examined in healthy male volunteers and male patients with major affective or personality disorder. GH[CLON] values were found to correlate significantly with the BDHI "Irritability" subscale in all subjects, but especially in healthy volunteer and personality disorder patients. GH[CLON] values did not correlate with the BDHI "Assault" subscale. These results suggest a role for central alpha-2-adrenergic receptor responsivity in the personality trait characterized by behavioral irritability, but not overt assaultiveness, in humans.