SUBSTANCE-P IN THE VENTROLATERAL MEDULLA-OBLONGATA REGULATES VENTILATORY RESPONSES
SUBSTANCE-P IN THE VENTROLATERAL MEDULLA-OBLONGATA REGULATES VENTILATORY RESPONSES
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DOI：
10.1152/jappl.1990.68.6.2631
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发表时间：
1990-06-01
影响因子：
3.3
通讯作者：
HEDNER, T
中科院分区：
文献类型：
--
作者：
CHEN, ZB;HEDNER, J;HEDNER, T
将 P 物质 (SP) 局部注射到腹外侧延髓 (VLM) 的巨细胞核、外侧直肠核和面后核的腹侧部分或直接应用于延髓的腹侧表面，引起潮气量 (VT) 和/或每分钟通气量 (.ovrhdot.E) 的显着刺激。 SP 后，VLM 对缺氧的通气反应显着减弱，但延髓背侧 (DM)（孤束核）却没有。 SP 拮抗剂 [D-Pro2,D-Trp7,9]SP 局部应用于 VLM 浅层大面积区域（而非 DM）时几乎完全抑制这种反应。在VLM（梯形体和从舌下核根部延伸到第一颈段的尾部区域）中单侧或双侧应用0.3-1.5 nmol SP拮抗剂可显着减弱对5% CO2吸入的反应。 The inhibition of the CO2 response was seen after [D-Pro2,D-Trp7,9]SP in the rostal areas of the medulla oblongata corresponding to the corpus trapezoideum and the caudal region extending from the rootlets of the nucleus hypoglossus to the first cervical segment of the cervical cord.电体感诱导的通气刺激可以被.apprx抑制。 70% 由 [D-Pro2,D-Trp7,9]SP 局部施用于 VLM 表面。我们得出结论，SP 参与大鼠的缺氧、高碳酸血症和体感通气反应。然而，这些呼吸反射是通过延髓中不同的神经元池（主要是 VLM）介导的。
Local injection of substance P (SP) into the ventral portion of the nucleus gigantocellularis, nucleus recticularis lateralis, and nucleus retrofacialis of the ventrolateral medulla oblongata (VLM) or direct application on the ventral surface of the medulla oblongata caused marked stimulation of tidal volume (VT) and/or minute ventilation (.ovrhdot.E). The ventilatory response to hypoxia was significnatly blunted after SP in the VLM but not in the dorsal medulla oblongata (DM) (nucleus tractus solitarius). The SP antagonist [D-Pro2,D-Trp7,9]SP almost completely inhibited this response when applied locally to a wide area of the superficial layer of the VLM but not of the DM. Unilateral or bilateral application of 0.3-1.5 nmol of the SP antagonist in the VLM (corpus trapezoideum and the caudal region extending from the rootlets of the nucleus hypoglossus to the first cervical segment) markedly attenuated the response to a 5% CO2 inhalation. The inhibition of the CO2 response was seen after [D-Pro2,D-Trp7,9]SP in the rostal areas of the medulla oblongata corresponding to the corpus trapezoideum and the caudal region extending from the rootlets of the nucleus hypoglossus to the first cervical segment of the cervical cord. Electric somatosensory-induced ventilatory stimulation could be depressed by .apprx. 70% by [D-Pro2,D-Trp7,9]SP locally applied on the surface of the VLM. We conclude that SP is involved in the hypoxic, hypercapnic, and somatosensory ventilatory response in the rat. However, these respiratory reflexes are mediated via different neuronal pools in the medulla oblongata, mainly the VLM.