Investigating the Use of Hair to Assess Polybrominated Diphenyl Ether Exposure Retrospectively
Investigating the Use of Hair to Assess Polybrominated Diphenyl Ether Exposure Retrospectively
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DOI：
10.1097/ftd.0b013e3182a69a8b
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发表时间：
2014-04-01
影响因子：
2.5
通讯作者：
Koren, Gideon
中科院分区：
文献类型：
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作者：
Carnevale, Amanda;Aleksa, Katarina;Koren, Gideon
背景：多溴联苯醚（PBDEs）是作为阻燃剂添加到各种消费品中的化学品，已被列为新兴的内分泌干扰物。它们具有持久性，并已在人体中检测到。先前的研究表明，头发是检测人类接触多溴联苯醚等有机污染物的合适基质。据信，大部分接触来自我们的室内环境。本研究的目的是调查多溴二苯醚的模式和水平沿着的毛干的变化，通过使用分段分析，回顾性评估长期暴露超过1 yearperiod.Methods：从65名妇女的样本和头发样本收集在医院为患病儿童，在多伦多，作为一个更大的研究的一部分。为了评估长期稳定性，将毛发样品分成4 cm和3 cm的片段，代表1年的时间。利用气相色谱-质谱法分析了毛发片段中8种多溴二苯醚同系物（BDE-28、BDE-47、BDE-99、BDE-100、BDE-153、BDE-154、BDE-183和BDE-209）的含量。Friedman检验用于检测各部分之间的暴露差异，并调查了饮食习惯、头发护理常规和居住地点等因素，以确定它们是否可能影响头发水平。在从近端到远端的节段中，PBDEs总量显著增加（P < 0.0001）。（根端）沿毛干沿着至远端（中位数，皮克/毫克）：第一段（33.3）、第二段（43.0）、第三段（61.6）和第四段（75.5）。在人工染色的头发样本中观察到的多溴二苯醚水平显著较低（P = 0.032），而在每天吃肉的妇女中观察到的多溴二苯醚水平显著增加，而不是每周消费（P = 0.040）。结论：多溴二苯醚沿着发干的增加表明，头发中的多溴二苯醚可能受到饮食和人工染色的影响。需要开展更多的工作来验证头发中的多溴二苯醚作为长期接触的生物标志物的用途。
Background:Polybrominated diphenyl ethers (PBDEs) are chemicals that are added to a variety of consumer products as flame-retardants and have been classified as emerging endocrine disruptors. They are persistent and have been detected in humans. Previous studies have suggested that hair is a suitable matrix for examining human exposure to organic pollutants such as PBDEs. It is believed that the majority of exposure is from our indoor environment. The aim of this study was to investigate the changes in PBDE patterns and levels along the hair shaft, by using segmental analysis to retrospectively assess long-term exposure over a 1-year period.Methods:Questionnaires and hair samples from 65 women were collected at the Hospital for Sick Children, in Toronto, as part of a larger study. To assess long-term stability, hair samples were separated into 4- and 3-cm segments representing a 1-year period. Hair segments were analyzed for levels of 8 PBDE congeners, BDE-28, BDE-47, BDE-99, BDE-100, BDE-153, BDE-154, BDE-183, and BDE-209 on gas chromatography-mass spectrometry (MS). A Friedman test was used to detect the differences in exposure among segments, and factors such as dietary habits, hair care routine, and site of residence were investigated to determine if they might affect hair levels.Results:A significant increase (P < 0.0001) in total PBDEs was seen among segments moving from proximal (root end) to distal along the hair shaft (median in pg/mg): first (33.3), second (43.0), third (61.6), and fourth (75.5) segments. Significantly lower levels of PBDEs were observed in artificially colored hair samples (P = 0.032), and a significant increase in PBDE levels was observed in women who consumed meat on a daily basis as opposed to weekly consumption (P = 0.040).Conclusions:The increase in PBDEs along the hair shaft suggests that hair PBDEs may be influenced by diet and artificial coloring. More work is needed to validate the use of PBDEs in hair as a biomarker of long-term exposure.