Cingulate cortical thickness in cocaine use disorder: mediation effect between early life stress and cocaine consumption.
Cingulate cortical thickness in cocaine use disorder: mediation effect between early life stress and cocaine consumption.
复制标题
可卡因使用障碍中的扣带皮层厚度：早期生活压力与可卡因消费之间的中介作用。
DOI：
10.1017/neu.2022.33
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发表时间：
2024
影响因子：
3.8
通讯作者：
Grassi-Oliveira,Rodrigo
中科院分区：
文献类型：
--
作者：
Bittencourt,AugustoMartinsLucas;Silveira,BárbaraLuizaBelmonteda;Tondo,LuccaPizzato;Rothmann,LeonardoMelo;Franco,AlexandreRosa;Ferreira,PedroEugenioMazzucchiSantana;Viola,ThiagoWendt;Grassi-Oliveira,Rodrigo
扣带回与成瘾的神经生物学有关，例如慢性可卡因消费。早期生活压力（ELS）是可卡因使用障碍（CUD）的重要调节剂。因此，我们研究了扣带回皮质厚度的影响，并测试是否有ELS的历史可以影响CUD.MethodsParticipants年龄在18-50岁（78 CUD由于快克可卡因消费和53名健康对照）的影响进行了磁共振成像和扣带回厚度（喙前部，尾前部，后部，峡部区域）进行了分析。临床评估包括儿童期创伤问卷（CTQ）和成瘾严重程度指数。组比较调整性别，年龄和教育进行。调解模型生成终身可卡因的使用，CTQ评分，皮质厚度对应的自变量，中介变量，和outcome.ResultsGroup比较显示显着差异，在六个扣带皮层，显示较低的厚度在CUD组。此外，经常使用可卡因的年份是与扣带回厚度最相关的变量。CTQ评分与扣带回峡部（右半球）以及前扣带回喙部（左半球）呈负相关。在中介分析中，我们观察到终身可卡因使用对扣带回峡部的显著负向直接效应和由CTQ评分介导的可卡因使用的间接效应。结论我们的研究结果表明，ELS史可加重慢性可卡因使用对扣带回的负向效应，特别是在右侧扣带回峡部皮质
ObjectiveThe cingulate gyrus is implicated in the neurobiology of addiction, such as chronic cocaine consumption. Early life stress (ELS) is an important moderator of cocaine use disorder (CUD). Therefore, we investigated the effect of CUD on cingulate cortical thickness and tested whether a history of ELS could influence the effects of CUD.MethodsParticipants aged 18–50 years (78 with CUD due to crack cocaine consumption and 53 healthy controls) underwent magnetic resonance imaging and the cingulate thickness (rostral anterior, caudal anterior, posterior, and isthmus regions) was analysed. The clinical assessment comprised the Childhood Trauma Questionnaire (CTQ) and the Addiction Severity Index. Group comparisons adjusting by sex, age, and education were performed. Mediation models were generated where lifetime cocaine use, CTQ score, and cortical thickness corresponded to the independent variable, intermediary variable, and outcome, respectively.ResultsGroup comparisons revealed significant differences in six out of eight cingulate cortices, showing lower thickness in the CUD group. Furthermore, years of regular cocaine use was the variable most associated with cingulate thickness. Negative correlations were found between CTQ scores and the isthmus cingulate (right hemisphere), as well as with the rostral anterior cingulate (left hemisphere). In the mediation analysis, we observed a significant negative direct effect of lifetime cocaine use on the isthmus cingulate and an indirect effect of cocaine use mediated by CTQ score.ConclusionOur findings suggest that a history of ELS could aggravate the negative effects of chronic cocaine use on the cingulate gyrus, particularly in the right isthmus cingulate cortex