Ageing affects dual encoding of periodicity and envelope shape in rat inferior colliculus neurons.
Ageing affects dual encoding of periodicity and envelope shape in rat inferior colliculus neurons.
复制标题
老化会影响大鼠下丘神经元中周期性和包膜形状的双重编码。
DOI：
10.1111/ejn.13463
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Bartlett EL
中科院分区：
文献类型：
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作者：
Herrmann B;Parthasarathy A;Bartlett EL
提取声音的时间周期性和包络形状对于在复杂的听觉场景中收听很重要，但随着年龄的增长而下降。在这里，我们记录了局部场电位（LFPs）和尖峰，以探讨衰老如何影响大鼠下丘不同调制率和包络形状的神经表征。我们的具体目标是探索下丘神经元的输入-输出（LFP-锋电位）反应转换。我们的研究结果表明，包络形状高达256赫兹的调制率表示在年轻和老年动物的神经同步相位滞后。重要的是，衰老与以下因素相关：（1）从LFP到尖峰的起始响应幅度的增强;（2）对于低调制速率（45 Hz），从LFP到尖峰的神经同步强度的增强;（3）对于较高调制速率（128和256 Hz），LFP同步强度的降低;以及（4）不同包络形状的神经同步强度的变化。目前年龄相关的变化进行了讨论的背景下，改变兴奋抑制平衡伴随着老化。振幅调制的声音，年轻和老年大鼠，而本地场电位（LFPs）和尖峰记录下丘神经元。衰老与从LFP到尖峰的起始反应和神经同步强度（对于45 Hz调制速率）的增强增益相关，并且与较高调制速率（128，256 Hz）的LFP同步强度的降低相关。这些变化可能是由于改变兴奋抑制平衡伴随着老化。
Extracting temporal periodicities and envelope shapes of sounds is important for listening within complex auditory scenes but declines behaviorally with age. Here we recorded local field potentials (LFPs) and spikes to investigate how aging affects the neural representations of different modulation rates and envelope shapes in the inferior colliculus of rats. We specifically aimed to explore the input-output (LFP-spike) response transformations of inferior colliculus neurons. Our results show that envelope shapes up to 256-Hz modulation rates are represented in the neural synchronization phase lags in younger and older animals. Critically, aging was associated with (1) an enhanced gain in onset response magnitude from LFPs to spikes; (2) an enhanced gain in neural synchronization strength from LFPs to spikes for a low modulation rate (45 Hz); (3) a decrease in LFP synchronization strength for higher modulation rates (128 and 256 Hz); and (4) changes in neural synchronization strength to different envelope shapes. The current age-related changes are discussed in the context of an altered excitation-inhibition balance accompanying aging. Amplitude-modulated sounds were presented to younger and older rats while local field potentials (LFPs) and spikes were recorded from inferior colliculus neurons. Aging was associated with an enhanced gain in onset response and neural synchronization strength (for a 45-Hz modulation rate) from LFPs to spikes, and with a decrease in LFP synchronization strength for higher modulation rates (128, 256 Hz). These changes might be due to an altered excitation-inhibition balance accompanying aging.